ID   NRDH_SHIFL              Reviewed;          81 AA.
AC   P0AC68; Q47414;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Glutaredoxin-like protein NrdH;
GN   Name=nrdH; OrderedLocusNames=SF2701, S2887;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Electron transport system for the ribonucleotide reductase
CC       system NrdEF. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glutaredoxin family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN44194.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18021.1; -; Genomic_DNA.
DR   RefSeq; NP_708487.1; NC_004337.2.
DR   RefSeq; WP_001223227.1; NZ_WPGW01000014.1.
DR   AlphaFoldDB; P0AC68; -.
DR   SMR; P0AC68; -.
DR   STRING; 198214.SF2701; -.
DR   PRIDE; P0AC68; -.
DR   EnsemblBacteria; AAN44194; AAN44194; SF2701.
DR   EnsemblBacteria; AAP18021; AAP18021; S2887.
DR   GeneID; 1025701; -.
DR   GeneID; 67414033; -.
DR   KEGG; sfl:SF2701; -.
DR   KEGG; sfx:S2887; -.
DR   PATRIC; fig|198214.7.peg.3216; -.
DR   HOGENOM; CLU_026126_9_0_6; -.
DR   OrthoDB; 2045232at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0097573; F:glutathione oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR011909; GlrX_NrdH.
DR   InterPro; IPR002109; Glutaredoxin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00462; Glutaredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR02194; GlrX_NrdH; 1.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Electron transport; Redox-active center;
KW   Reference proteome; Transport.
FT   CHAIN           1..81
FT                   /note="Glutaredoxin-like protein NrdH"
FT                   /id="PRO_0000141642"
FT   DOMAIN          1..81
FT                   /note="Glutaredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT   DISULFID        11..14
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   81 AA;  9139 MW;  6D0878E9CD133137 CRC64;
     MRITIYTRND CVQCHATKRA MENRGFDFEM INVDRVPEAA EALRAQGFRQ LPVVIAGDLS
     WSGFRPDMIN RLHPAPHAAS A