ID   NRDR_BDEBA              Reviewed;         194 AA.
AC   Q6MNX8;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=Bd1098;
OS   Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 /
OS   HD100).
OC   Bacteria; Proteobacteria; Oligoflexia; Bdellovibrionales;
OC   Bdellovibrionaceae; Bdellovibrio.
OX   NCBI_TaxID=264462;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100;
RX   PubMed=14752164; DOI=10.1126/science.1093027;
RA   Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C.,
RA   Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E.,
RA   Schuster S.C.;
RT   "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a
RT   genomic perspective.";
RL   Science 303:689-692(2004).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE79021.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX842648; CAE79021.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011163623.1; NC_005363.1.
DR   AlphaFoldDB; Q6MNX8; -.
DR   STRING; 264462.Bd1098; -.
DR   PRIDE; Q6MNX8; -.
DR   EnsemblBacteria; CAE79021; CAE79021; Bd1098.
DR   KEGG; bba:Bd1098; -.
DR   eggNOG; COG1327; Bacteria.
DR   HOGENOM; CLU_108412_0_1_7; -.
DR   OrthoDB; 1551627at2; -.
DR   Proteomes; UP000008080; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..194
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000182269"
FT   DOMAIN          48..138
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..33
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   REGION          168..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   194 AA;  21999 MW;  76ECBC5368944C1D CRC64;
     MKCPFCGHAD DRVLDTRVQK DGSIRRRREC LECKARFSTV ETIMLAFPFI IKKDGRREPF
     SKEKILKGLQ ASCQKRPVSL AQIDAVVEKI SAWVINRGES EISSRLIGKK VMAELKQLDD
     VAYIRFASVY RTFKDVQEFV ETLEDAELLD FVDASNPQLS LTAMTFVESE KSTNHETDSK
     TPSPRTRPPG PLSN