NRDR_BURMA
ID NRDR_BURMA Reviewed; 159 AA.
AC Q62I17;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=BMA2074;
OS Burkholderia mallei (strain ATCC 23344).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=243160;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23344;
RX PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M., Daugherty S.C.,
RA Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J., Durkin A.S.,
RA Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F., Madupu R., Mohammoud Y.,
RA Nelson W.C., Radune D., Romero C.M., Sarria S., Selengut J., Shamblin C.,
RA Sullivan S.A., White O., Yu Y., Zafar N., Zhou L., Fraser C.M.;
RT "Structural flexibility in the Burkholderia mallei genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC Rule:MF_00440}.
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DR EMBL; CP000010; AAU49634.1; -; Genomic_DNA.
DR RefSeq; WP_004185666.1; NC_006348.1.
DR RefSeq; YP_103653.1; NC_006348.1.
DR AlphaFoldDB; Q62I17; -.
DR SMR; Q62I17; -.
DR STRING; 243160.BMA2074; -.
DR EnsemblBacteria; AAU49634; AAU49634; BMA2074.
DR GeneID; 56594917; -.
DR KEGG; bma:BMA2074; -.
DR PATRIC; fig|243160.12.peg.2145; -.
DR eggNOG; COG1327; Bacteria.
DR HOGENOM; CLU_108412_0_0_4; -.
DR OMA; YRFTTYE; -.
DR Proteomes; UP000006693; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR PANTHER; PTHR30455; PTHR30455; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR TIGRFAMs; TIGR00244; TIGR00244; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..159
FT /note="Transcriptional repressor NrdR"
FT /id="PRO_0000182277"
FT DOMAIN 49..139
FT /note="ATP-cone"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT ZN_FING 3..34
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ SEQUENCE 159 AA; 18427 MW; 5ECC191B60527844 CRC64;
MRCPFCRHDD TQVVDSRVSE DGAAIRRRRR CSACDKRFTT YERVELALPA VVKKDGSRTE
FDRRKIVASM QLALRKRPVA ADAIDAAVAR IEYQLLASGE REVRSEKLGE LVMNELRQLD
TIAYVRFASV YRRFEDVSEF EDVIEEFRRA APAKTPRKR