NRDR_CHLAD
ID NRDR_CHLAD Reviewed; 174 AA.
AC B8G2S3;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=Cagg_0279;
OS Chloroflexus aggregans (strain MD-66 / DSM 9485).
OC Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Chloroflexaceae; Chloroflexus.
OX NCBI_TaxID=326427;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-66 / DSM 9485;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Bryant D.A., Richardson P.;
RT "Complete sequence of Chloroflexus aggregans DSM 9485.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC Rule:MF_00440}.
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DR EMBL; CP001337; ACL23227.1; -; Genomic_DNA.
DR RefSeq; WP_012615593.1; NC_011831.1.
DR AlphaFoldDB; B8G2S3; -.
DR SMR; B8G2S3; -.
DR STRING; 326427.Cagg_0279; -.
DR EnsemblBacteria; ACL23227; ACL23227; Cagg_0279.
DR KEGG; cag:Cagg_0279; -.
DR eggNOG; COG1327; Bacteria.
DR HOGENOM; CLU_108412_0_0_0; -.
DR OMA; YRFTTYE; -.
DR OrthoDB; 1551627at2; -.
DR Proteomes; UP000002508; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR PANTHER; PTHR30455; PTHR30455; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR TIGRFAMs; TIGR00244; TIGR00244; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..174
FT /note="Transcriptional repressor NrdR"
FT /id="PRO_1000191785"
FT DOMAIN 49..139
FT /note="ATP-cone"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT ZN_FING 3..34
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT REGION 151..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 174 AA; 20042 MW; BB39594955223570 CRC64;
MRCPICHFPE TDVIDTRKLY EGEVIRRRRK CRACGRRFTT YERIESVSLM VVKKDGTREP
YDREKIARGV RTACYRRPVS ADAIEQLVNE VETAVMATDQ QEISSQFIGD AVMRRLRDLD
EVAYIRFASV YRSFADIGKL REAVDELLER EGTRNGHSSA ATTDQGTTDN HSRM