ID   NRDR_CLAM3              Reviewed;         157 AA.
AC   A5CS39;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=CMM_1847;
OS   Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382).
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae; Clavibacter.
OX   NCBI_TaxID=443906;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCPPB 382;
RX   PubMed=18192381; DOI=10.1128/jb.01595-07;
RA   Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M.,
RA   Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O.,
RA   Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C.,
RA   Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O.,
RA   Bartels D.;
RT   "The genome sequence of the tomato-pathogenic actinomycete Clavibacter
RT   michiganensis subsp. michiganensis NCPPB382 reveals a large island involved
RT   in pathogenicity.";
RL   J. Bacteriol. 190:2138-2149(2008).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
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DR   EMBL; AM711867; CAN01903.1; -; Genomic_DNA.
DR   RefSeq; WP_012038534.1; NC_009480.1.
DR   AlphaFoldDB; A5CS39; -.
DR   SMR; A5CS39; -.
DR   STRING; 443906.CMM_1847; -.
DR   EnsemblBacteria; CAN01903; CAN01903; CMM_1847.
DR   GeneID; 56886179; -.
DR   KEGG; cmi:CMM_1847; -.
DR   eggNOG; COG1327; Bacteria.
DR   HOGENOM; CLU_108412_1_0_11; -.
DR   OMA; YRFTTYE; -.
DR   OrthoDB; 1551627at2; -.
DR   Proteomes; UP000001564; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..157
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_1000080731"
FT   DOMAIN          46..136
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ   SEQUENCE   157 AA;  17312 MW;  FDCF7A204F2E898B CRC64;
     MFCPFCRHPD SRVVDSRTSD DGLSIRRRRQ CPECGRRFST TETASLSVIK RNGVVEPFSR
     EKIVTGVRKA CQGRPVTDTD LAVLAQRVEE AIRATGASQI EANDIGLSIL PPLRELDEVA
     YLRFASVYQG FDSLDDFESA IAQLRVAHAA TPDADAL