ID   NRDR_CLOAB              Reviewed;         151 AA.
AC   P33661;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 2.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=CA_C1698;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=7961408; DOI=10.1128/jb.176.21.6572-6582.1994;
RA   Sauer U., Treuner A., Buchholz M., Santangelo J.D., Durre P.;
RT   "Sporulation and primary sigma factor homologous genes in Clostridium
RT   acetobutylicum.";
RL   J. Bacteriol. 176:6572-6582(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA80620.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Z23079; CAA80620.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE001437; AAK79664.1; -; Genomic_DNA.
DR   PIR; E97109; E97109.
DR   PIR; I40624; I40624.
DR   RefSeq; NP_348324.1; NC_003030.1.
DR   RefSeq; WP_010965005.1; NC_003030.1.
DR   AlphaFoldDB; P33661; -.
DR   SMR; P33661; -.
DR   STRING; 272562.CA_C1698; -.
DR   EnsemblBacteria; AAK79664; AAK79664; CA_C1698.
DR   GeneID; 44998193; -.
DR   KEGG; cac:CA_C1698; -.
DR   PATRIC; fig|272562.8.peg.1901; -.
DR   eggNOG; COG1327; Bacteria.
DR   HOGENOM; CLU_108412_0_0_9; -.
DR   OMA; YRFTTYE; -.
DR   OrthoDB; 1551627at2; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..151
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000182285"
FT   DOMAIN          49..139
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ   SEQUENCE   151 AA;  17641 MW;  C6A49DEF5FC2EFA1 CRC64;
     MKCPFCGYSE SKVVDSRSTE DNMAIRRRRE CLECSKRYTT YEKVEDIPIL VIKKDSSREF
     FDKSKVINGL IKSCEKRPVS RQQIEDIASD VEKSISNQMV TEVKSDAIGE MVMEKLKEID
     EIAYVRFASV YRQFKDINTF MEEILNLVNK K