ID   NRDR_CLOPS              Reviewed;         149 AA.
AC   Q0SS62;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=CPR_1730;
OS   Clostridium perfringens (strain SM101 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=289380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM101 / Type A;
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA   Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA   Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA   Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA   Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA   Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT   Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
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DR   EMBL; CP000312; ABG86714.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0SS62; -.
DR   SMR; Q0SS62; -.
DR   EnsemblBacteria; ABG86714; ABG86714; CPR_1730.
DR   KEGG; cpr:CPR_1730; -.
DR   OMA; YRFTTYE; -.
DR   Proteomes; UP000001824; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..149
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000264170"
FT   DOMAIN          49..139
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ   SEQUENCE   149 AA;  17761 MW;  2BDDF561B19FEA4B CRC64;
     MRCPYCSYEE SKVVDSRSAE DYNAIRRRRE CLRCSKRYTT YEKVEDIPIL VIKKDLSRES
     FNKEKIISGL IKACQKRPVS RAQIEEIASD IERNISNKMM VEIKSDYIGE MIMERLKDID
     EVSYVRFASV YRQFKDINTF MEEIKNLMK