ID   NRDR_CUTAK              Reviewed;         168 AA.
AC   Q6A8Y9;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=PPA1025;
OS   Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium
OS   acnes).
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Cutibacterium.
OX   NCBI_TaxID=267747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16379 / KPA171202;
RX   PubMed=15286373; DOI=10.1126/science.1100330;
RA   Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A.,
RA   Strittmatter A., Hujer S., Duerre P., Gottschalk G.;
RT   "The complete genome sequence of Propionibacterium acnes, a commensal of
RT   human skin.";
RL   Science 305:671-673(2004).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT82777.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017283; AAT82777.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002517883.1; NZ_CP025935.1.
DR   AlphaFoldDB; Q6A8Y9; -.
DR   SMR; Q6A8Y9; -.
DR   STRING; 267747.PPA1025; -.
DR   EnsemblBacteria; AAT82777; AAT82777; PPA1025.
DR   GeneID; 66621113; -.
DR   KEGG; pac:PPA1025; -.
DR   PATRIC; fig|267747.3.peg.1061; -.
DR   eggNOG; COG1327; Bacteria.
DR   HOGENOM; CLU_108412_1_0_11; -.
DR   OMA; YRFTTYE; -.
DR   Proteomes; UP000000603; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..168
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000182333"
FT   DOMAIN          46..136
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   REGION          145..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   168 AA;  19336 MW;  C74E804F16FD80AE CRC64;
     MRCPFCQHDD SRVLDSRVCE DGTAIRRRRQ CPMCERRFTT IERMQMTVHK RNGIEEPFSR
     DKVIRGVRNA CKGRPVTDAD LALLGQRVED GLRARGVAEI PSEEIGLAIL GPLRELDSIA
     YLRFASVYLN YNTIEDFATE IDRLRDESSD KTKSSSRKRL SKQDEPLF