NRDR_ECOLI
ID NRDR_ECOLI Reviewed; 149 AA.
AC P0A8D0; P25538; Q2MC13; Q3ZUB1;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Transcriptional repressor NrdR;
GN Name=nrdR; Synonyms=ybaD; OrderedLocusNames=b0413, JW0403;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=1406588; DOI=10.1007/bf00538702;
RA Taura T., Ueguchi C., Shiba K., Ito K.;
RT "Insertional disruption of the nusB (ssyB) gene leads to cold-sensitive
RT growth of Escherichia coli and suppression of the secY24 mutation.";
RL Mol. Gen. Genet. 234:429-432(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RA Borovok I., Aharonowitz Y., Cohen G.;
RT "Phylogeny and distribution of nrdR orthologous genes in bacteria.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP FUNCTION AS A REGULATOR OF RIBONUCLEOTIDE REDUCTASE GENES.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=17496099; DOI=10.1128/jb.00440-07;
RA Torrents E., Grinberg I., Gorovitz-Harris B., Lundstroem H., Borovok I.,
RA Aharonowitz Y., Sjoeberg B.M., Cohen G.;
RT "NrdR controls differential expression of the Escherichia coli
RT ribonucleotide reductase genes.";
RL J. Bacteriol. 189:5012-5021(2007).
CC -!- FUNCTION: Represses transcription of the class Ib RNR genes nrdHIEF but
CC has much smaller effect on transcription of the class Ia RNR genes
CC nrdAB and class III RNR genes nrdDG. By binding to nrdR boxes in the
CC promoter regions to alter promoter activity, nrdR differentially
CC regulates nrdAB, nrdHIEF and nrdD transcription in aerobic growth.
CC {ECO:0000269|PubMed:17496099}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 1 zinc ion. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000305}.
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DR EMBL; X64395; CAA45734.1; -; Genomic_DNA.
DR EMBL; AM076828; CAJ28592.1; -; Genomic_DNA.
DR EMBL; U82664; AAB40169.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73516.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76193.1; -; Genomic_DNA.
DR PIR; S26200; S26200.
DR RefSeq; NP_414947.1; NC_000913.3.
DR RefSeq; WP_000543535.1; NZ_STEB01000007.1.
DR AlphaFoldDB; P0A8D0; -.
DR SMR; P0A8D0; -.
DR BioGRID; 4259833; 28.
DR BioGRID; 851757; 5.
DR DIP; DIP-31842N; -.
DR IntAct; P0A8D0; 18.
DR STRING; 511145.b0413; -.
DR jPOST; P0A8D0; -.
DR PaxDb; P0A8D0; -.
DR PRIDE; P0A8D0; -.
DR EnsemblBacteria; AAC73516; AAC73516; b0413.
DR EnsemblBacteria; BAE76193; BAE76193; BAE76193.
DR GeneID; 67416512; -.
DR GeneID; 947437; -.
DR KEGG; ecj:JW0403; -.
DR KEGG; eco:b0413; -.
DR PATRIC; fig|511145.12.peg.429; -.
DR EchoBASE; EB1296; -.
DR eggNOG; COG1327; Bacteria.
DR HOGENOM; CLU_108412_0_0_6; -.
DR InParanoid; P0A8D0; -.
DR OMA; YRFTTYE; -.
DR PhylomeDB; P0A8D0; -.
DR BioCyc; EcoCyc:EG11320-MON; -.
DR PRO; PR:P0A8D0; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005524; F:ATP binding; IDA:EcoCyc.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:EcoCyc.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR PANTHER; PTHR30455; PTHR30455; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR TIGRFAMs; TIGR00244; TIGR00244; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 1: Evidence at protein level;
KW ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..149
FT /note="Transcriptional repressor NrdR"
FT /id="PRO_0000182296"
FT DOMAIN 49..139
FT /note="ATP-cone"
FT ZN_FING 3..34
FT /evidence="ECO:0000250"
SQ SEQUENCE 149 AA; 17229 MW; EFF99DD555EF2D26 CRC64;
MHCPFCFAVD TKVIDSRLVG EGSSVRRRRQ CLVCNERFTT FEVAELVMPR VVKSNDVREP
FNEEKLRSGM LRALEKRPVS SDDVEMAINH IKSQLRATGE REVPSKMIGN LVMEQLKKLD
KVAYIRFASV YRSFEDIKEF GEEIARLED
