NRDR_FUSNN
ID NRDR_FUSNN Reviewed; 149 AA.
AC Q8R605;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=FN1490;
OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX NCBI_TaxID=190304;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC 2640 / LMG 13131 / VPI 4355;
RX PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA Overbeek R.;
RT "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT strain ATCC 25586.";
RL J. Bacteriol. 184:2005-2018(2002).
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC Rule:MF_00440}.
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DR EMBL; AE009951; AAL95684.1; -; Genomic_DNA.
DR RefSeq; NP_604384.1; NC_003454.1.
DR AlphaFoldDB; Q8R605; -.
DR SMR; Q8R605; -.
DR STRING; 190304.FN1490; -.
DR EnsemblBacteria; AAL95684; AAL95684; FN1490.
DR KEGG; fnu:FN1490; -.
DR PATRIC; fig|190304.8.peg.2050; -.
DR eggNOG; COG1327; Bacteria.
DR HOGENOM; CLU_108412_0_0_0; -.
DR InParanoid; Q8R605; -.
DR OMA; YRFTTYE; -.
DR BioCyc; FNUC190304:G1FZS-2058-MON; -.
DR Proteomes; UP000002521; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR PANTHER; PTHR30455; PTHR30455; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR TIGRFAMs; TIGR00244; TIGR00244; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..149
FT /note="Transcriptional repressor NrdR"
FT /id="PRO_0000182299"
FT DOMAIN 48..138
FT /note="ATP-cone"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT ZN_FING 3..33
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ SEQUENCE 149 AA; 17590 MW; B77A1E89ADD6245E CRC64;
MKCPFCSSED TKVVDSRTTI DGSTKRRREC NNCLKRFSTY ERFEESPIYV VKKDNRRVKY
DREKLLRGLT FATAKRNVSR EELDKIITDI ERSLQNSLIS EISSKDLGEK VLEKLRELDQ
VAYVRFASVY KEFDDIKSFI EIVEEIKKD