NRDR_GEOKA
ID NRDR_GEOKA Reviewed; 153 AA.
AC Q5KWC8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=GK2723;
OS Geobacillus kaustophilus (strain HTA426).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=235909;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTA426;
RX PubMed=15576355; DOI=10.1093/nar/gkh970;
RA Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA Matsui S., Uchiyama I.;
RT "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT Geobacillus kaustophilus.";
RL Nucleic Acids Res. 32:6292-6303(2004).
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC Rule:MF_00440}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD77008.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BA000043; BAD77008.1; ALT_FRAME; Genomic_DNA.
DR AlphaFoldDB; Q5KWC8; -.
DR SMR; Q5KWC8; -.
DR STRING; 235909.GK2723; -.
DR PRIDE; Q5KWC8; -.
DR EnsemblBacteria; BAD77008; BAD77008; GK2723.
DR KEGG; gka:GK2723; -.
DR eggNOG; COG1327; Bacteria.
DR HOGENOM; CLU_108412_0_0_9; -.
DR Proteomes; UP000001172; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR PANTHER; PTHR30455; PTHR30455; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR TIGRFAMs; TIGR00244; TIGR00244; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..153
FT /note="Transcriptional repressor NrdR"
FT /id="PRO_0000182300"
FT DOMAIN 49..139
FT /note="ATP-cone"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT ZN_FING 3..34
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ SEQUENCE 153 AA; 18192 MW; 5E7A9BE241D8C014 CRC64;
MRCPSCHHSG TRVLESRPVE EGRSIRRRRE CEQCHYRFTT FERIEEPPLI VVKKEGTREE
FSREKILRGL IKACEKRPVA LEELEKVTQE IERELRNQGV SEVKSETIGE MVMERLSHID
EVAYVRFASV YRQFKDINVF IEELKELIKK GQR