ID   NRDR_HALMD              Reviewed;         162 AA.
AC   C7P544;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Transcriptional repressor NrdR;
GN   Name=nrdR; OrderedLocusNames=Hmuk_3351;
OS   Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB
OS   13541) (Haloarcula mukohataei).
OG   Plasmid pHmuk01.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Halomicrobium.
OX   NCBI_TaxID=485914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541;
RX   PubMed=21304667; DOI=10.4056/sigs.42644;
RA   Tindall B.J., Schneider S., Lapidus A., Copeland A., Glavina Del Rio T.,
RA   Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Saunders E., Bruce D.,
RA   Goodwin L., Pitluck S., Mikhailova N., Pati A., Ivanova N., Mavrommatis K.,
RA   Chen A., Palaniappan K., Chain P., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Brettin T., Han C., Rohde M., Goker M., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.,
RA   Detter J.C.;
RT   "Complete genome sequence of Halomicrobium mukohataei type strain (arg-
RT   2).";
RL   Stand. Genomic Sci. 1:270-277(2009).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000305}.
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DR   EMBL; CP001689; ACV49439.1; -; Genomic_DNA.
DR   RefSeq; WP_012807516.1; NC_013201.1.
DR   AlphaFoldDB; C7P544; -.
DR   SMR; C7P544; -.
DR   STRING; 485914.Hmuk_3351; -.
DR   EnsemblBacteria; ACV49439; ACV49439; Hmuk_3351.
DR   GeneID; 8409429; -.
DR   KEGG; hmu:Hmuk_3351; -.
DR   eggNOG; arCOG08098; Archaea.
DR   HOGENOM; CLU_108412_0_0_2; -.
DR   OrthoDB; 102022at2157; -.
DR   Proteomes; UP000001746; Plasmid pHmuk01.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Plasmid;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..162
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000399920"
FT   DOMAIN          49..139
FT                   /note="ATP-cone"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   162 AA;  18570 MW;  E9294767F120071D CRC64;
     MNCPDCGNER TRVIDTETSA DGTSVRRRRE CQRCSFRFTT YERPEWESLQ VKKRDGTIES
     FDRQKLRAGI ERAVEKRDVT ETTVTALVDD VESELQGREA RIVSSSLIGE LVSESLRTLD
     KVAYIRFVSV YKAFSEPQEF LRELDAVLDA ELDDFEASNS SQ