ID   NRDR_LACLA              Reviewed;         148 AA.
AC   Q9CHI1;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=LL0750;
GN   ORFNames=L157023;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
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DR   EMBL; AE005176; AAK04848.1; -; Genomic_DNA.
DR   PIR; F86718; F86718.
DR   RefSeq; NP_266906.1; NC_002662.1.
DR   RefSeq; WP_003132469.1; NC_002662.1.
DR   AlphaFoldDB; Q9CHI1; -.
DR   SMR; Q9CHI1; -.
DR   STRING; 272623.L157023; -.
DR   PaxDb; Q9CHI1; -.
DR   EnsemblBacteria; AAK04848; AAK04848; L157023.
DR   GeneID; 60355350; -.
DR   GeneID; 61109016; -.
DR   GeneID; 66441702; -.
DR   KEGG; lla:L157023; -.
DR   PATRIC; fig|272623.7.peg.804; -.
DR   eggNOG; COG1327; Bacteria.
DR   HOGENOM; CLU_108412_0_0_9; -.
DR   OMA; YRFTTYE; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..148
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000182308"
FT   DOMAIN          47..137
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..32
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ   SEQUENCE   148 AA;  17374 MW;  0E97C0250681D94E CRC64;
     MRCPKCSSEE SKVVDSRQAE DAIRRRRVCE SCGFRFTTFE RIEEMPLLVI KKDDKREPFN
     REKIVRGLVR SAYKRPVSSE DIETTVANVE RKIRQLDSNE VESDVIGEFV MQELAELDDI
     TYIRFASVYR SFKDVSELEE LLKNITKK