ID   NRDR_STRCL              Reviewed;         172 AA.
AC   O86848;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440};
OS   Streptomyces clavuligerus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL
RC   3585 / VKM Ac-602;
RA   Kreisberg-Zakarin R., Borovok I., Schreiber R., Holmgren A., Aslund F.,
RA   Reichard P., Cohen G., Aharonowitz Y.;
RT   "Streptomyces clavuligerus vitamin B12-dependent ribonucleotide reductase
RT   enzyme: from protein to gene.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=15949864; DOI=10.1016/j.tig.2005.05.011;
RA   Rodionov D.A., Gelfand M.S.;
RT   "Identification of a bacterial regulatory system for ribonucleotide
RT   reductases by phylogenetic profiling.";
RL   Trends Genet. 21:385-389(2005).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440, ECO:0000269|PubMed:15949864}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
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DR   EMBL; AJ224870; CAA12170.1; -; Genomic_DNA.
DR   RefSeq; WP_003956102.1; NZ_CP032052.1.
DR   AlphaFoldDB; O86848; -.
DR   SMR; O86848; -.
DR   STRING; 443255.SCLAV_4683; -.
DR   GeneID; 61469248; -.
DR   eggNOG; COG1327; Bacteria.
DR   OMA; YRFTTYE; -.
DR   OrthoDB; 1551627at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..172
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000182364"
FT   DOMAIN          46..136
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   REGION          152..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  18689 MW;  F3846A5190251ED2 CRC64;
     MHCPFCRHPD SRVVDSRTTD DGTSIRRRRQ CPDCSRRFTT VETASLMVIK RSGVTEPFSR
     TKVISGVRKA CQGRPVTEDA LAQLGQRVEE AVRATGSAEL TTHDVGLAIL GPLQELDLVA
     YLRFASVYRA FDSLEDFEAA IAELREHRLP AERSGGGTCG TGTVPVPAGT AD