NRDR_STRPN
ID NRDR_STRPN Reviewed; 157 AA.
AC P67318; P58260;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=SP_1713;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC -!- INTERACTION:
CC P67318; Q37990: orf6; Xeno; NbExp=2; IntAct=EBI-11615955, EBI-3990391;
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC Rule:MF_00440}.
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DR EMBL; AE005672; AAK75791.1; -; Genomic_DNA.
DR PIR; F95199; F95199.
DR RefSeq; WP_001203672.1; NZ_AKVY01000001.1.
DR AlphaFoldDB; P67318; -.
DR SMR; P67318; -.
DR IntAct; P67318; 1.
DR STRING; 170187.SP_1713; -.
DR EnsemblBacteria; AAK75791; AAK75791; SP_1713.
DR GeneID; 60232530; -.
DR GeneID; 66806787; -.
DR KEGG; spn:SP_1713; -.
DR eggNOG; COG1327; Bacteria.
DR OMA; YRFTTYE; -.
DR PhylomeDB; P67318; -.
DR BioCyc; SPNE170187:G1FZB-1736-MON; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR PANTHER; PTHR30455; PTHR30455; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR TIGRFAMs; TIGR00244; TIGR00244; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 1: Evidence at protein level;
KW ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..157
FT /note="Transcriptional repressor NrdR"
FT /id="PRO_0000182357"
FT DOMAIN 49..139
FT /note="ATP-cone"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT ZN_FING 3..34
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 157 AA; 18380 MW; 7AF69B2A7E47249F CRC64;
MRCPKCGATK SSVIDSRQAE EGNTIRRRRE CDECQHRFTT YERVEERTLV VVKKDGTREQ
FSRDKIFNGI IRSAQKRPVS SDEINMVVNR IEQKLRGRNE NEIQSEDIGS LVMEELAELD
EITYVRFASV YRSFKDVSEL ESLLQQITQS SKKKKER
