NRDR_STRR6
ID NRDR_STRR6 Reviewed; 157 AA.
AC P67319; P58260;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=spr1557;
OS Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=171101;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-255 / R6;
RX PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL J. Bacteriol. 183:5709-5717(2001).
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC Rule:MF_00440}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL00361.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE007317; AAL00361.1; ALT_INIT; Genomic_DNA.
DR PIR; D98066; D98066.
DR RefSeq; NP_359150.2; NC_003098.1.
DR RefSeq; WP_001203672.1; NC_003098.1.
DR AlphaFoldDB; P67319; -.
DR SMR; P67319; -.
DR STRING; 171101.spr1557; -.
DR EnsemblBacteria; AAL00361; AAL00361; spr1557.
DR GeneID; 60232530; -.
DR GeneID; 66806787; -.
DR KEGG; spr:spr1557; -.
DR PATRIC; fig|171101.6.peg.1681; -.
DR eggNOG; COG1327; Bacteria.
DR HOGENOM; CLU_108412_0_0_9; -.
DR Proteomes; UP000000586; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR PANTHER; PTHR30455; PTHR30455; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR TIGRFAMs; TIGR00244; TIGR00244; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..157
FT /note="Transcriptional repressor NrdR"
FT /id="PRO_0000182358"
FT DOMAIN 49..139
FT /note="ATP-cone"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT ZN_FING 3..34
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 157 AA; 18380 MW; 7AF69B2A7E47249F CRC64;
MRCPKCGATK SSVIDSRQAE EGNTIRRRRE CDECQHRFTT YERVEERTLV VVKKDGTREQ
FSRDKIFNGI IRSAQKRPVS SDEINMVVNR IEQKLRGRNE NEIQSEDIGS LVMEELAELD
EITYVRFASV YRSFKDVSEL ESLLQQITQS SKKKKER
