ID   NRDR_SYNP6              Reviewed;         168 AA.
AC   P46227;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=syc0835_d;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7862084; DOI=10.1007/bf00294676;
RA   Sugita M., Sugita C., Sugiura M.;
RT   "Structure and expression of the gene encoding ribosomal protein S1 from
RT   the cyanobacterium Synechococcus sp. strain PCC 6301: striking sequence
RT   similarity to the chloroplast ribosomal protein CS1.";
RL   Mol. Gen. Genet. 246:142-147(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
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DR   EMBL; D28752; BAA05945.1; -; Genomic_DNA.
DR   EMBL; AP008231; BAD79025.1; -; Genomic_DNA.
DR   RefSeq; WP_011243147.1; NC_006576.1.
DR   AlphaFoldDB; P46227; -.
DR   SMR; P46227; -.
DR   STRING; 269084.syc0835_d; -.
DR   EnsemblBacteria; BAD79025; BAD79025; syc0835_d.
DR   KEGG; syc:syc0835_d; -.
DR   eggNOG; COG1327; Bacteria.
DR   OMA; YRFTTYE; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455; PTHR30455; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..168
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000182368"
FT   DOMAIN          49..139
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   168 AA;  19106 MW;  37E7D90C5E90137D CRC64;
     MQCPACRHTD SRVLESRSSE SGRSVRRRRE CLSCGHRFTT YERVEFVPIS VIKRNGDRES
     FDRSKLLRGI VRACEKTGVS AQQMDLLVDE IEGTLQQRSS RDVQSSEIGE MVLQQIGRLS
     EVAYIRFASV YRQFRGVRDF VETLDRLQDL SRDEVGDVPA AVTSLTSA