ID   NREA_ARCFU              Reviewed;         391 AA.
AC   A0A1B2LS07; O28922; O28923;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2016, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=DNA repair protein NreA {ECO:0000305};
GN   Name=nreA {ECO:0000303|PubMed:26337406};
GN   OrderedLocusNames=AF_1346/AF_1347 {ECO:0000312|EMBL:AAB89912.1,
GN   ECO:0000312|EMBL:AAB89916.1};
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE, PIP MOTIF, AND POTENTIAL
RP   METAL-BINDING SITE.
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=26337406; DOI=10.1111/mmi.13210;
RA   Giroux X., MacNeill S.A.;
RT   "A novel archaeal DNA repair factor that acts with the UvrABC system to
RT   repair mitomycin C-induced DNA damage in a PCNA-dependent manner.";
RL   Mol. Microbiol. 99:1-14(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [3]
RP   INTERACTION WITH PCNA.
RX   PubMed=11805086; DOI=10.1074/jbc.m107793200;
RA   Motz M., Kober I., Girardot C., Loeser E., Bauer U., Albers M., Moeckel G.,
RA   Minch E., Voss H., Kilger C., Koegl M.;
RT   "Elucidation of an archaeal replication protein network to generate
RT   enhanced PCR enzymes.";
RL   J. Biol. Chem. 277:16179-16188(2002).
CC   -!- FUNCTION: Involved in DNA damage repair. {ECO:0000255|HAMAP-
CC       Rule:MF_02096}.
CC   -!- SUBUNIT: Interacts with the DNA polymerase sliding clamp (PCNA) via the
CC       PIP (PCNA-interacting peptide) motif. {ECO:0000255|HAMAP-Rule:MF_02096,
CC       ECO:0000269|PubMed:11805086}.
CC   -!- DOMAIN: Contains a predicted C4 metal binding domain at the N-terminus,
CC       which could be a zinc finger DNA binding domain. {ECO:0000255|HAMAP-
CC       Rule:MF_02096, ECO:0000305|PubMed:26337406}.
CC   -!- SIMILARITY: Belongs to the Nre family. {ECO:0000255|HAMAP-
CC       Rule:MF_02096, ECO:0000305|PubMed:26337406}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB89912.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAB89916.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; KU605081; AOA49614.1; -; Genomic_DNA.
DR   EMBL; AE000782; AAB89912.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE000782; AAB89916.1; ALT_FRAME; Genomic_DNA.
DR   PIR; A69418; A69418.
DR   PIR; B69418; B69418.
DR   AlphaFoldDB; A0A1B2LS07; -.
DR   STRING; 224325.AF_1346; -.
DR   EnsemblBacteria; AAB89912; AAB89912; AF_1346.
DR   EnsemblBacteria; AAB89916; AAB89916; AF_1347.
DR   KEGG; afu:AF_1346; -.
DR   KEGG; afu:AF_1347; -.
DR   eggNOG; arCOG04269; Archaea.
DR   HOGENOM; CLU_039703_0_0_2; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02096; Nre; 1.
DR   InterPro; IPR033167; Nre.
DR   InterPro; IPR006979; Nre_C.
DR   InterPro; IPR006978; Nre_N.
DR   PANTHER; PTHR38136; PTHR38136; 1.
DR   Pfam; PF04895; Nre_C; 1.
DR   Pfam; PF04894; Nre_N; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA repair; Metal-binding; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..391
FT                   /note="DNA repair protein NreA"
FT                   /id="PRO_0000442519"
FT   ZN_FING         6..20
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02096,
FT                   ECO:0000305|PubMed:26337406"
FT   MOTIF           382..389
FT                   /note="PIP motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02096,
FT                   ECO:0000305|PubMed:26337406"
SQ   SEQUENCE   391 AA;  45223 MW;  5B42ECEBD1D3ED1B CRC64;
     MVSVRCAECK GKLLCGRSKC PLLEKYRFLK EIKIDSRILD PSPPSIFVGR VGYPKVYAGP
     LVSINADPVY ADSPWLWKSI EEVIRLRTSM LRVSRRFRVE DVREEKKELT EMQEMTAAIK
     PVDVEAEIRK ISRKAEFDDV MQPMGYSAIA ESIKLAENPK IPDKVEKVYY DDMKAYEALS
     YLYNHGFSTY YLQKIFSAGI LGERKSRKLV PTRWSITAVH SIVGEAIKRE IAAYKPIDKT
     LLFNYEHFGN HFEVILSPEN YFFQLVEIWQ RKSFWSPKED WIGVDSEDIR PKRDYSNLSG
     GYYAARLPVL EYLREKRGQA SVLVIREIKP SYYAPLGVWV VEEGVRKALK SKPEVFESFD
     DALTAASRRV ENKEWRALVS RQTSLASFFG F