ID   NREB_ARCFU              Reviewed;         391 AA.
AC   O28682;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=DNA repair protein NreB {ECO:0000305};
GN   Name=nreB {ECO:0000303|PubMed:26337406};
GN   OrderedLocusNames=AF_1590 {ECO:0000312|EMBL:AAB89664.1};
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2]
RP   NOMENCLATURE, PIP MOTIF, AND POTENTIAL METAL-BINDING SITE.
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=26337406; DOI=10.1111/mmi.13210;
RA   Giroux X., MacNeill S.A.;
RT   "A novel archaeal DNA repair factor that acts with the UvrABC system to
RT   repair mitomycin C-induced DNA damage in a PCNA-dependent manner.";
RL   Mol. Microbiol. 99:1-14(2016).
CC   -!- FUNCTION: Involved in DNA damage repair. {ECO:0000255|HAMAP-
CC       Rule:MF_02096}.
CC   -!- SUBUNIT: Interacts with the DNA polymerase sliding clamp (PCNA) via the
CC       PIP (PCNA-interacting peptide) motif. {ECO:0000255|HAMAP-
CC       Rule:MF_02096}.
CC   -!- DOMAIN: Contains a predicted C4 metal binding domain at the N-terminus,
CC       which could be a zinc finger DNA binding domain. {ECO:0000255|HAMAP-
CC       Rule:MF_02096, ECO:0000305|PubMed:26337406}.
CC   -!- SIMILARITY: Belongs to the Nre family. {ECO:0000255|HAMAP-
CC       Rule:MF_02096, ECO:0000305|PubMed:26337406}.
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DR   EMBL; AE000782; AAB89664.1; -; Genomic_DNA.
DR   PIR; E69448; E69448.
DR   AlphaFoldDB; O28682; -.
DR   STRING; 224325.AF_1590; -.
DR   EnsemblBacteria; AAB89664; AAB89664; AF_1590.
DR   KEGG; afu:AF_1590; -.
DR   eggNOG; arCOG04269; Archaea.
DR   HOGENOM; CLU_039703_0_0_2; -.
DR   OMA; EIYPGFN; -.
DR   OrthoDB; 17407at2157; -.
DR   PhylomeDB; O28682; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02096; Nre; 1.
DR   InterPro; IPR033167; Nre.
DR   InterPro; IPR006979; Nre_C.
DR   InterPro; IPR006978; Nre_N.
DR   PANTHER; PTHR38136; PTHR38136; 1.
DR   Pfam; PF04895; Nre_C; 1.
DR   Pfam; PF04894; Nre_N; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA repair; Metal-binding; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..391
FT                   /note="DNA repair protein NreB"
FT                   /id="PRO_0000442520"
FT   ZN_FING         3..17
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02096,
FT                   ECO:0000305|PubMed:26337406"
FT   MOTIF           384..391
FT                   /note="PIP motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02096,
FT                   ECO:0000305|PubMed:26337406"
SQ   SEQUENCE   391 AA;  45273 MW;  642744DD5AC3DC28 CRC64;
     MDCIECRGRM LCSRKVCPLM PSLRPQVSVE RDILGSSPPS VFVGRYGYPK VRICPAVPPF
     TGDTKIYDTP EMWREVPVER VLEFRYSMIL GQFRADVRRS KEVEVVQEMS LYDKPIDVEV
     SFAKPPSVRA FFDDVLPPFG ASAPAKEVII HSAPRPPKAV EKVYYDTDLR AVEAMSYLYE
     RGVAVSHIQK LLSAGTLGVK RKLVPTRWAI TAVDDTLSKQ IIEEIKQYET IDRYRVFVLK
     ESKNLFVAIL CPSPWSYEWG EAWYPDTTWN RTRKVGVLTD SEGFFGRTTY ARLGGCYYSS
     RLATAEYLRR IRRQATAIVW REIYPGFNVP IGVWFVREML RKMYAGKYCE FDTLEDALRF
     VDKHSNLDVG RWIEKSTLVK RGRQRTLWEF M