NREC_STAHJ
ID NREC_STAHJ Reviewed; 217 AA.
AC Q4L8Q6;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Oxygen regulatory protein NreC;
DE AltName: Full=Nitrogen regulation protein C;
GN Name=nreC; OrderedLocusNames=SH0660;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- FUNCTION: Member of the two-component regulatory system NreB/NreC
CC involved in the control of dissimilatory nitrate/nitrite reduction in
CC response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic
CC sequence at the promoters of the nitrate (narGHJI) and nitrite (nir)
CC reductase operons, as well as the putative nitrate transporter gene
CC narT, and activates their expression (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by NreB. {ECO:0000250}.
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DR EMBL; AP006716; BAE03969.1; -; Genomic_DNA.
DR RefSeq; WP_011274985.1; NC_007168.1.
DR AlphaFoldDB; Q4L8Q6; -.
DR SMR; Q4L8Q6; -.
DR STRING; 279808.SH0660; -.
DR EnsemblBacteria; BAE03969; BAE03969; SH0660.
DR GeneID; 58063149; -.
DR KEGG; sha:SH0660; -.
DR eggNOG; COG2197; Bacteria.
DR HOGENOM; CLU_000445_90_1_9; -.
DR OMA; LDKYATH; -.
DR OrthoDB; 1687028at2; -.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..217
FT /note="Oxygen regulatory protein NreC"
FT /id="PRO_0000349359"
FT DOMAIN 2..119
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 148..213
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 172..191
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 217 AA; 24462 MW; 3EC3FE0DBC02C553 CRC64;
MKIVIADDHA VVRTGFSMIL NFQEDMEVVA TAADGGEAYQ KVMEHKPDVL IMDLSMPPGE
SGLIATSKIS ESFPETKILI LTMYDDEEYL FHVLRNGAKG YILKNAPDEQ LLLAVRTVYK
GETYVDMKLT TSLVNEFVNH KHSDDVSTND PFKILSKREL EILPLIAKGY GNKDIAEKLF
VSVKTVEAHK THIMTKLDLK SKPELVEYAL KKKLLDF