ID   NREP_MACFA              Reviewed;          68 AA.
AC   Q4R541;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Neuronal regeneration-related protein;
DE   AltName: Full=Neuronal protein 3.1;
DE   AltName: Full=Protein p311;
GN   Name=NREP; ORFNames=QccE-20026;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have roles in neural function and cellular
CC       differentiation. Ectopic expression promotes axonal regeneration,
CC       induces differentiation of fibroblast into myofibroblast, induces
CC       myofibroblast ameboid migration, augments motility of gliomas, and
CC       increases retinoic-acid regulation of lipid-droplet biogenesis. Down-
CC       regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play
CC       a role in the regulation of alveolar generation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the latency-associated peptides (LAP) of TGFB1
CC       and TGFB2; the interaction results in a decrease in TGFB autoinduction.
CC       Interacts with FLNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated on Ser-59. Phosphorylation decreases stability and
CC       activity. {ECO:0000250}.
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DR   EMBL; AB169703; BAE01784.1; -; mRNA.
DR   RefSeq; XP_005557559.1; XM_005557502.2.
DR   RefSeq; XP_005557561.1; XM_005557504.2.
DR   RefSeq; XP_005557562.1; XM_005557505.1.
DR   RefSeq; XP_005557563.1; XM_005557506.2.
DR   AlphaFoldDB; Q4R541; -.
DR   STRING; 9541.XP_005557559.1; -.
DR   Ensembl; ENSMFAT00000074118; ENSMFAP00000051701; ENSMFAG00000062127.
DR   GeneID; 101864800; -.
DR   KEGG; mcf:101864800; -.
DR   CTD; 9315; -.
DR   VEuPathDB; HostDB:ENSMFAG00000022681; -.
DR   eggNOG; ENOG502SFKT; Eukaryota.
DR   GeneTree; ENSGT00390000016521; -.
DR   OMA; TIWVSQK; -.
DR   Proteomes; UP000233100; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024417; Neuronal_3.1.
DR   PANTHER; PTHR17102; PTHR17102; 1.
DR   Pfam; PF11092; Alveol-reg_P311; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..68
FT                   /note="Neuronal regeneration-related protein"
FT                   /id="PRO_0000253595"
FT   REGION          21..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   68 AA;  7951 MW;  50E9667249CA4F22 CRC64;
     MVYYPERFVW VSQEPFPNKN MEGRLPKGRL PVPKEVNRKK NDETNAASLT PLGSSELRSP
     RISYLHFF