ID   NREP_PONAB              Reviewed;          68 AA.
AC   Q5NVD3;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Neuronal regeneration-related protein;
DE   AltName: Full=Neuronal protein 3.1;
DE   AltName: Full=Protein p311;
GN   Name=NREP; Synonyms=P311;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have roles in neural function and cellular
CC       differentiation. Ectopic expression promotes axonal regeneration,
CC       induces differentiation of fibroblast into myofibroblast, induces
CC       myofibroblast ameboid migration, augments motility of gliomas, and
CC       increases retinoic-acid regulation of lipid-droplet biogenesis. Down-
CC       regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play
CC       a role in the regulation of alveolar generation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the latency-associated peptides (LAP) of TGFB1
CC       and TGFB2; the interaction results in a decrease in TGFB autoinduction.
CC       Interacts with FLNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated on Ser-59. Phosphorylation decreases stability and
CC       activity. {ECO:0000250}.
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DR   EMBL; CR926104; CAI29730.1; -; mRNA.
DR   RefSeq; NP_001127120.1; NM_001133648.1.
DR   AlphaFoldDB; Q5NVD3; -.
DR   STRING; 9601.ENSPPYP00000019872; -.
DR   GeneID; 100174166; -.
DR   KEGG; pon:100174166; -.
DR   CTD; 9315; -.
DR   eggNOG; ENOG502SFKT; Eukaryota.
DR   InParanoid; Q5NVD3; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024417; Neuronal_3.1.
DR   PANTHER; PTHR17102; PTHR17102; 1.
DR   Pfam; PF11092; Alveol-reg_P311; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..68
FT                   /note="Neuronal regeneration-related protein"
FT                   /id="PRO_0000253596"
FT   REGION          21..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   68 AA;  7789 MW;  520D5BC93CC15137 CRC64;
     MVYYPELSVW VSQEPFPNKD MEGRLPKGRL PVPKEVNRKK NDETNAASLT PLGSSELRSP
     RISYLHSF