NREP_RAT
ID NREP_RAT Reviewed; 68 AA.
AC Q80Z34;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Neuronal regeneration-related protein;
DE AltName: Full=Neuronal protein 3.1;
DE AltName: Full=Protein p311;
GN Name=Nrep; Synonyms=P311;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Che Y., Yamashita T., Yoshikawa H., Tohyama M.;
RT "Differentiation-inducing factor, NREP, accelerates nerve regeneration.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION.
RX PubMed=15485502; DOI=10.1111/j.1471-4159.2004.02738.x;
RA Fujitani M., Yamagishi S., Che Y.H., Hata K., Kubo T., Ino H., Tohyama M.,
RA Yamashita T.;
RT "P311 accelerates nerve regeneration of the axotomized facial nerve.";
RL J. Neurochem. 91:737-744(2004).
CC -!- FUNCTION: May have roles in neural function. Ectopic expression
CC promotes axonal regeneration. Augments also motility of gliomas (By
CC similarity). May also have roles in cellular differentiation (By
CC similarity). Induces differentiation of fibroblast into myofibroblast
CC and myofibroblast ameboid migration (By similarity). Increases
CC retinoic-acid regulation of lipid-droplet biogenesis (By similarity).
CC Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By
CC similarity). May play a role in the regulation of alveolar generation
CC (By similarity). {ECO:0000250, ECO:0000269|PubMed:15485502}.
CC -!- SUBUNIT: Interacts with FLNA. Interacts with the latency-associated
CC peptides (LAP) of TGFB1 and TGFB2; the interaction results in a
CC decrease in TGFB autoinduction. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated on Ser-59. Phosphorylation decreases stability and
CC activity. {ECO:0000250}.
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DR EMBL; AB072344; BAC65245.1; -; mRNA.
DR RefSeq; NP_835197.1; NM_178096.3.
DR RefSeq; XP_006254657.1; XM_006254595.2.
DR AlphaFoldDB; Q80Z34; -.
DR STRING; 10116.ENSRNOP00000027739; -.
DR PaxDb; Q80Z34; -.
DR Ensembl; ENSRNOT00000119499; ENSRNOP00000086813; ENSRNOG00000068914.
DR GeneID; 338475; -.
DR KEGG; rno:338475; -.
DR UCSC; RGD:631411; rat.
DR CTD; 9315; -.
DR RGD; 631411; Nrep.
DR eggNOG; ENOG502SFKT; Eukaryota.
DR GeneTree; ENSGT00390000016521; -.
DR HOGENOM; CLU_204758_0_0_1; -.
DR InParanoid; Q80Z34; -.
DR OMA; IPPGNHE; -.
DR OrthoDB; 1603548at2759; -.
DR PhylomeDB; Q80Z34; -.
DR TreeFam; TF336368; -.
DR PRO; PR:Q80Z34; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000020467; Expressed in quadriceps femoris and 18 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0031103; P:axon regeneration; IEP:RGD.
DR GO; GO:0045664; P:regulation of neuron differentiation; IMP:RGD.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR InterPro; IPR024417; Neuronal_3.1.
DR PANTHER; PTHR17102; PTHR17102; 1.
DR Pfam; PF11092; Alveol-reg_P311; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..68
FT /note="Neuronal regeneration-related protein"
FT /id="PRO_0000253597"
SQ SEQUENCE 68 AA; 7648 MW; FE6F4D1E8C7B6C0C CRC64;
MVYYPELLVW VSQEPFPYKE MEGGLTKGRL PVPKEVNRKK MDEPIAASLI PPGNHEPGSP
AIGYLHPF
