ID   NRF1_RAT                Reviewed;          52 AA.
AC   Q62792;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Nuclear respiratory factor 1;
DE            Short=NRF-1;
DE   AltName: Full=Alpha palindromic-binding protein;
DE            Short=Alpha-pal;
DE   Flags: Fragment;
GN   Name=Nrf1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=7629110; DOI=10.1074/jbc.270.30.18019;
RA   Gopalakrishnan L., Scarpulla R.C.;
RT   "Structure, expression, and chromosomal assignment of the human gene
RT   encoding nuclear respiratory factor 1.";
RL   J. Biol. Chem. 270:18019-18025(1995).
CC   -!- FUNCTION: Transcription factor that activates the expression of the
CC       EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key
CC       metabolic genes to cellular growth and development. Implicated in the
CC       control of nuclear genes required for respiration, heme biosynthesis,
CC       and mitochondrial DNA transcription and replication (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Binds DNA as a dimer. Interacts with PPRC1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in the lung and testis, at
CC       intermediate levels in the kidney, heart and brain and at low levels in
CC       the muscle and liver.
CC   -!- PTM: Phosphorylation enhances DNA binding. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NRF1/Ewg family. {ECO:0000305}.
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DR   EMBL; U27700; AAA79014.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q62792; -.
DR   STRING; 10116.ENSRNOP00000011851; -.
DR   PaxDb; Q62792; -.
DR   UCSC; RGD:1304603; rat.
DR   RGD; 1304603; Nrf1.
DR   eggNOG; KOG1491; Eukaryota.
DR   InParanoid; Q62792; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
DR   GO; GO:0007005; P:mitochondrion organization; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0051602; P:response to electrical stimulus; IDA:RGD.
DR   GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR   GO; GO:0051593; P:response to folic acid; IEP:RGD.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>52
FT                   /note="Nuclear respiratory factor 1"
FT                   /id="PRO_0000100210"
FT   NON_TER         1
FT   NON_TER         52
SQ   SEQUENCE   52 AA;  5339 MW;  AF282130457BFEB1 CRC64;
     VEQNWATLQG GEMTIQTTQA SEATQAVASL AEAAVAASQE MQQGATVTMA LN