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NRFC_ECOLI
ID   NRFC_ECOLI              Reviewed;         223 AA.
AC   P0AAK7; P32708; Q2M6N2;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protein NrfC;
DE   Flags: Precursor;
GN   Name=nrfC; Synonyms=yjcJ; OrderedLocusNames=b4072, JW4033;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8057835; DOI=10.1111/j.1365-2958.1994.tb01004.x;
RA   Hussain H.A., Grove J., Griffiths L., Busby S., Cole J.;
RT   "A seven-gene operon essential for formate-dependent nitrite reduction to
RT   ammonia by enteric bacteria.";
RL   Mol. Microbiol. 12:153-163(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA   Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT   "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT   from 89.2 to 92.8 minutes.";
RL   Nucleic Acids Res. 21:5408-5417(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP   65-66.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   EXPORT VIA THE TAT-SYSTEM.
RX   PubMed=17218314; DOI=10.1074/jbc.m610507200;
RA   Tullman-Ercek D., DeLisa M.P., Kawarasaki Y., Iranpour P., Ribnicky B.,
RA   Palmer T., Georgiou G.;
RT   "Export pathway selectivity of Escherichia coli twin arginine translocation
RT   signal peptides.";
RL   J. Biol. Chem. 282:8309-8316(2007).
CC   -!- FUNCTION: Probably involved in the transfer of electrons from the
CC       quinone pool to the type-c cytochromes.
CC   -!- PTM: Exported by the Tat system. The position of the signal peptide
CC       cleavage has not been experimentally proven.
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DR   EMBL; X72298; CAA51043.1; -; Genomic_DNA.
DR   EMBL; U00006; AAC43166.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77042.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78074.1; -; Genomic_DNA.
DR   PIR; C57987; C57987.
DR   RefSeq; NP_418496.1; NC_000913.3.
DR   RefSeq; WP_000220281.1; NZ_STEB01000014.1.
DR   AlphaFoldDB; P0AAK7; -.
DR   SMR; P0AAK7; -.
DR   BioGRID; 4263519; 39.
DR   IntAct; P0AAK7; 3.
DR   STRING; 511145.b4072; -.
DR   jPOST; P0AAK7; -.
DR   PaxDb; P0AAK7; -.
DR   PRIDE; P0AAK7; -.
DR   EnsemblBacteria; AAC77042; AAC77042; b4072.
DR   EnsemblBacteria; BAE78074; BAE78074; BAE78074.
DR   GeneID; 67414711; -.
DR   GeneID; 948581; -.
DR   KEGG; ecj:JW4033; -.
DR   KEGG; eco:b4072; -.
DR   PATRIC; fig|1411691.4.peg.2632; -.
DR   EchoBASE; EB1889; -.
DR   eggNOG; COG0437; Bacteria.
DR   HOGENOM; CLU_043374_1_3_6; -.
DR   InParanoid; P0AAK7; -.
DR   OMA; CENTPCL; -.
DR   PhylomeDB; P0AAK7; -.
DR   BioCyc; EcoCyc:NRFC-MON; -.
DR   PRO; PR:P0AAK7; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042279; F:nitrite reductase (cytochrome, ammonia-forming) activity; IMP:EcoCyc.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR017567; Cyt_c_NO2Rdtase_NrfC.
DR   InterPro; IPR006311; TAT_signal.
DR   InterPro; IPR019546; TAT_signal_bac_arc.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF13247; Fer4_11; 1.
DR   TIGRFAMs; TIGR03149; cyt_nit_nrfC; 1.
DR   TIGRFAMs; TIGR01409; TAT_signal_seq; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 3.
DR   PROSITE; PS51318; TAT; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW   Oxidoreductase; Reference proteome; Repeat; Signal; Transport.
FT   SIGNAL          1..27
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT   CHAIN           28..223
FT                   /note="Protein NrfC"
FT                   /id="PRO_0000042276"
FT   DOMAIN          37..65
FT                   /note="4Fe-4S ferredoxin-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT   DOMAIN          83..114
FT                   /note="4Fe-4S ferredoxin-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT   DOMAIN          116..145
FT                   /note="4Fe-4S ferredoxin-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT   BINDING         46
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         49
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         52
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         56
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         92
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         95
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         100
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         104
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250"
FT   BINDING         125
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250"
FT   BINDING         128
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250"
FT   BINDING         131
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250"
FT   BINDING         135
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         152
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         155
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         168
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        65..66
FT                   /note="GV -> AS (in Ref. 2; AAC43166)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   223 AA;  24567 MW;  676C3264D341FC8E CRC64;
     MTWSRRQFLT GVGVLAAVSG TAGRVVAKTL NINGVRYGMV HDESLCIGCT ACMDACREVN
     KVPEGVSRLT IIRSEPQGEF PDVKYRFFRK SCQHCDHAPC VDVCPTGASF RDAASGIVDV
     NPDLCVGCQY CIAACPYRVR FIHPVTKTAD KCDFCRKTNL QAGKLPACVE ACPTKALTFG
     NLDDPNSEIS QLLRQKPTYR YKLALGTKPK LYRVPFKYGE VSQ
 
 
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