NRFD_ECOLI
ID NRFD_ECOLI Reviewed; 318 AA.
AC P32709; Q2M6N1;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein NrfD;
GN Name=nrfD; Synonyms=yjcK; OrderedLocusNames=b4073, JW4034;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8057835; DOI=10.1111/j.1365-2958.1994.tb01004.x;
RA Hussain H.A., Grove J., Griffiths L., Busby S., Cole J.;
RT "A seven-gene operon essential for formate-dependent nitrite reduction to
RT ammonia by enteric bacteria.";
RL Mol. Microbiol. 12:153-163(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT from 89.2 to 92.8 minutes.";
RL Nucleic Acids Res. 21:5408-5417(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Probably involved in the transfer of electrons from the
CC quinone pool to the type-c cytochromes.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15919996}.
CC -!- SIMILARITY: Belongs to the NrfD family. {ECO:0000305}.
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DR EMBL; X72298; CAA51044.1; -; Genomic_DNA.
DR EMBL; U00006; AAC43167.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77043.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78075.1; -; Genomic_DNA.
DR PIR; H65215; D57987.
DR RefSeq; NP_418497.1; NC_000913.3.
DR RefSeq; WP_000195171.1; NZ_SSZK01000016.1.
DR AlphaFoldDB; P32709; -.
DR SMR; P32709; -.
DR BioGRID; 4262676; 18.
DR STRING; 511145.b4073; -.
DR jPOST; P32709; -.
DR PaxDb; P32709; -.
DR PRIDE; P32709; -.
DR EnsemblBacteria; AAC77043; AAC77043; b4073.
DR EnsemblBacteria; BAE78075; BAE78075; BAE78075.
DR GeneID; 66672011; -.
DR GeneID; 948580; -.
DR KEGG; ecj:JW4034; -.
DR KEGG; eco:b4073; -.
DR PATRIC; fig|1411691.4.peg.2631; -.
DR EchoBASE; EB1890; -.
DR eggNOG; COG3301; Bacteria.
DR HOGENOM; CLU_045348_1_2_6; -.
DR InParanoid; P32709; -.
DR OMA; QFNSVMS; -.
DR PhylomeDB; P32709; -.
DR BioCyc; EcoCyc:NRFD-MON; -.
DR PRO; PR:P32709; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR InterPro; IPR017566; NrfD.
DR InterPro; IPR005614; NrfD_fam.
DR Pfam; PF03916; NrfD; 1.
DR TIGRFAMs; TIGR03148; cyt_nit_nrfD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Protein NrfD"
FT /id="PRO_0000159322"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 141
FT /note="L -> V (in Ref. 1; CAA51044)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="A -> R (in Ref. 1; CAA51044)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35042 MW; B650FB208C4C4FEE CRC64;
MTQTSAFHFE SLVWDWPIAI YLFLIGISAG LVTLAVLLRR FYPQAGGADS TLLRTTLIVG
PGAVILGLLI LVFHLTRPWT FWKLMFHYSF TSVMSMGVML FQLYMVVLVL WLAKIFEHDL
LALQQRWLPK LGIVQKVLSL LTPVHRGLET LMLVLAVLLG AYTGFLLSAL KSYPFLNNPI
LPVLFLFSGI SSGAAVALIA MAIRQRSNPH STEAQFVHRM EIPVVWGEIF LLVAFFVGLA
LGDDGKVRAL VAALGGGFWT WWFWLGVAGL GLIVPMLLKP WVNRSSGIPA VLAACGASLV
GVLMLRFFIL YAGQLTVA
