NRFE_HAEIN
ID NRFE_HAEIN Reviewed; 635 AA.
AC P44944;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Cytochrome c-type biogenesis protein NrfE;
GN Name=nrfE; OrderedLocusNames=HI_0936;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC subunit of a heme lyase (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L42023; AAC22594.1; -; Genomic_DNA.
DR PIR; A64162; A64162.
DR RefSeq; NP_439096.1; NC_000907.1.
DR RefSeq; WP_005693283.1; NC_000907.1.
DR AlphaFoldDB; P44944; -.
DR SMR; P44944; -.
DR STRING; 71421.HI_0936; -.
DR EnsemblBacteria; AAC22594; AAC22594; HI_0936.
DR KEGG; hin:HI_0936; -.
DR PATRIC; fig|71421.8.peg.977; -.
DR eggNOG; COG1138; Bacteria.
DR HOGENOM; CLU_015041_3_0_6; -.
DR OMA; EFWLEDN; -.
DR PhylomeDB; P44944; -.
DR BioCyc; HINF71421:G1GJ1-976-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR032523; CcmF_C.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003567; Cyt_c_biogenesis.
DR InterPro; IPR003568; Cyt_c_biogenesis_CcmF.
DR InterPro; IPR003570; Cyt_c_biogenesis_NrfE.
DR InterPro; IPR017563; CytC_NO3Rdtase_biogenesis_NrfE.
DR PANTHER; PTHR43653; PTHR43653; 2.
DR Pfam; PF16327; CcmF_C; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01410; CCBIOGENESIS.
DR PRINTS; PR01413; NRFEBIOGNSIS.
DR TIGRFAMs; TIGR03145; cyt_nit_nrfE; 1.
DR TIGRFAMs; TIGR00353; nrfE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..635
FT /note="Cytochrome c-type biogenesis protein NrfE"
FT /id="PRO_0000201590"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 607..627
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 635 AA; 71274 MW; B979E54F1ED534FC CRC64;
MLPELGFFLL LLATASAFFL ALVPQFGLFK KNPTLINAAW PLSYIFTLAT TLSIGLLAYS
FAVDDFTLEY VAAHSNSQLP TFFKVAATWG GHEGSMLFWL FSLSLWLAAF AFFNRKNDRT
FSAQSLSLLG LICFGFAVFI LFYSNPFGRI FPAPAEGRDL NPMLQDVGLI FHPPLLYVGY
VGFAVNFAMS LSALIYNQSA RQIARSMRGW VLVSWLFLTI GIVLGAWWAY YELGWGGWWF
WDPVENASLM PWLLGLALLH SLMATEKQGV FSYWTTLFSL LAFAFSVLGT FIVRSGALTS
VHAFALDNTR GYVLLLIFFV LTALAFGLFA LRAGSSSESA VKFQFISKSG GILLLNILLT
IATVSTFLGT FYPMLFQAMN WGSISVGSPY FNSIFFPIIT AILILMVIVL SIRKGQFDRT
LLIRCGWLLI PSLILAGLMI WQQLRNNSAL HFHAFAFVLL TLAIWLLFVT LWQNWRQIRL
SQFGMILAHC GVAIVTIGAV MSGYFGSEIG VRLAPQQSQT LGQYEFHYRQ FSNEIGPNFT
AEVAFFDVTK NGKPYAEIIP ERRYYDVRTM TMSEVGLDGG FWGDLYIVMG DSLGKGEFTF
RLHYKPLIRW LWAGGILMAF GALFSVFGLR RKQEK
