NRFF_HAEIN
ID NRFF_HAEIN Reviewed; 384 AA.
AC P44942;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Formate-dependent nitrite reductase complex bifunctional subunit NrfFG;
DE Flags: Precursor;
GN Name=nrfF; OrderedLocusNames=HI_0934;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Possible subunit of a heme lyase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CcmH/CycL/Ccl2/NrfF family. {ECO:0000305}.
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DR EMBL; L42023; AAC22592.1; -; Genomic_DNA.
DR PIR; H64161; H64161.
DR RefSeq; NP_439094.1; NC_000907.1.
DR RefSeq; WP_005693281.1; NC_000907.1.
DR AlphaFoldDB; P44942; -.
DR SMR; P44942; -.
DR STRING; 71421.HI_0934; -.
DR EnsemblBacteria; AAC22592; AAC22592; HI_0934.
DR KEGG; hin:HI_0934; -.
DR PATRIC; fig|71421.8.peg.975; -.
DR eggNOG; COG3088; Bacteria.
DR eggNOG; COG4235; Bacteria.
DR HOGENOM; CLU_036074_0_1_6; -.
DR OMA; QNNEFDS; -.
DR PhylomeDB; P44942; -.
DR BioCyc; HINF71421:G1GJ1-974-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0018378; P:cytochrome c-heme linkage via heme-L-cysteine; IBA:GO_Central.
DR Gene3D; 1.10.8.640; -; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR005616; CcmH/CycL/Ccl2/NrfF.
DR InterPro; IPR038297; CcmH/CycL/NrfF/Ccl2_sf.
DR InterPro; IPR017565; For-dep_Cytc_NO2Rdtase_NrfF.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF03918; CcmH; 1.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR TIGRFAMs; TIGR03147; cyt_nit_nrfF; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Heme; Iron; Metal-binding; Periplasm; Reference proteome; Repeat; Signal;
KW TPR repeat.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..384
FT /note="Formate-dependent nitrite reductase complex
FT bifunctional subunit NrfFG"
FT /id="PRO_0000006616"
FT REPEAT 221..254
FT /note="TPR 1"
FT REPEAT 255..288
FT /note="TPR 2"
FT REGION 36..144
FT /note="NrfF"
FT REGION 180..384
FT /note="NrfG"
FT BINDING 61
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255"
FT BINDING 64
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /note="covalent"
FT /evidence="ECO:0000255"
SQ SEQUENCE 384 AA; 43780 MW; 0321F4A7704964C4 CRC64;
MKSILDIFTR GFIQVQKTVF FATALLFAFS LFTQAEMVDT YQFQNQDDRT RAVELAKSLR
CPQCQNQNLV ESNSPIAYDL RLEVYKMVDE GKSNQQIIDK MTARFGDFVN YKPPFKWNTA
LLWLLPVALL ILAAVLLYFS NRKKQFSEKV VAQQLENDEI ISLPSTFGSS PRKQGEPSKL
SKGKVNSKIY FVLFTLLIAI PATYYFSLDR FSRVQQGEQS MIEQHNQNVE MNDEHKNENV
IEKLQNKLRT DPNNAETWLQ LGEAYVQNNE FDSALVAYSN AEKLSGSKPN ILGLAATALY
YQAGQQMTQK VEQLLNEALA KDKNEVSSLS LLATIALENR QYQQAGMYLQ QLLDSGNAAV
DRRSVIQRMK MLDFLQRGEK GQNP