ID   NRIP3_HUMAN             Reviewed;         241 AA.
AC   Q9NQ35; Q86WD9;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Nuclear receptor-interacting protein 3;
DE   AltName: Full=Sarcoma antigen NY-SAR-105;
GN   Name=NRIP3; Synonyms=C11orf14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11528127; DOI=10.1159/000056999;
RA   Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A.,
RA   Zabel B., Hankeln T., Schmidt E.R.;
RT   "Comparative genomic sequencing reveals a strikingly similar architecture
RT   of a conserved syntenic region on human chromosome 11p15.3 (including gene
RT   ST5) and mouse chromosome 7.";
RL   Cytogenet. Cell Genet. 93:284-290(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 64-241.
RX   PubMed=12601173; DOI=10.1073/pnas.0437972100;
RA   Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B.,
RA   Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J.;
RT   "Immunomic analysis of human sarcoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003).
CC   -!- INTERACTION:
CC       Q9NQ35; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-10311735, EBI-725606;
CC       Q9NQ35; Q16543: CDC37; NbExp=3; IntAct=EBI-10311735, EBI-295634;
CC       Q9NQ35; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-10311735, EBI-743105;
CC       Q9NQ35; Q8N6L0: KASH5; NbExp=6; IntAct=EBI-10311735, EBI-749265;
CC       Q9NQ35; P61970: NUTF2; NbExp=3; IntAct=EBI-10311735, EBI-591778;
CC       Q9NQ35; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-10311735, EBI-607755;
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DR   EMBL; AJ400877; CAB92286.1; -; Genomic_DNA.
DR   EMBL; AK024750; BAB14984.1; -; mRNA.
DR   EMBL; BC008835; AAH08835.1; -; mRNA.
DR   EMBL; AY211930; AAO65183.1; -; mRNA.
DR   CCDS; CCDS31422.1; -.
DR   RefSeq; NP_065696.1; NM_020645.2.
DR   AlphaFoldDB; Q9NQ35; -.
DR   SMR; Q9NQ35; -.
DR   BioGRID; 121183; 15.
DR   IntAct; Q9NQ35; 9.
DR   STRING; 9606.ENSP00000310205; -.
DR   MEROPS; A28.002; -.
DR   GlyConnect; 662; 1 N-Linked glycan (1 site).
DR   GlyGen; Q9NQ35; 1 site, 2 N-linked glycans (1 site).
DR   iPTMnet; Q9NQ35; -.
DR   PhosphoSitePlus; Q9NQ35; -.
DR   BioMuta; NRIP3; -.
DR   DMDM; 34395556; -.
DR   EPD; Q9NQ35; -.
DR   jPOST; Q9NQ35; -.
DR   MassIVE; Q9NQ35; -.
DR   MaxQB; Q9NQ35; -.
DR   PaxDb; Q9NQ35; -.
DR   PeptideAtlas; Q9NQ35; -.
DR   PRIDE; Q9NQ35; -.
DR   ProteomicsDB; 82070; -.
DR   Antibodypedia; 24183; 222 antibodies from 26 providers.
DR   DNASU; 56675; -.
DR   Ensembl; ENST00000309166.8; ENSP00000310205.3; ENSG00000175352.11.
DR   GeneID; 56675; -.
DR   KEGG; hsa:56675; -.
DR   MANE-Select; ENST00000309166.8; ENSP00000310205.3; NM_020645.3; NP_065696.1.
DR   UCSC; uc001mhg.2; human.
DR   CTD; 56675; -.
DR   DisGeNET; 56675; -.
DR   GeneCards; NRIP3; -.
DR   HGNC; HGNC:1167; NRIP3.
DR   HPA; ENSG00000175352; Tissue enhanced (brain, retina, testis).
DR   MIM; 613125; gene.
DR   neXtProt; NX_Q9NQ35; -.
DR   OpenTargets; ENSG00000175352; -.
DR   PharmGKB; PA25481; -.
DR   VEuPathDB; HostDB:ENSG00000175352; -.
DR   eggNOG; KOG0012; Eukaryota.
DR   GeneTree; ENSGT00950000182999; -.
DR   HOGENOM; CLU_087166_1_0_1; -.
DR   InParanoid; Q9NQ35; -.
DR   OMA; VVSCQCA; -.
DR   OrthoDB; 1182441at2759; -.
DR   PhylomeDB; Q9NQ35; -.
DR   TreeFam; TF333421; -.
DR   PathwayCommons; Q9NQ35; -.
DR   SignaLink; Q9NQ35; -.
DR   BioGRID-ORCS; 56675; 10 hits in 1073 CRISPR screens.
DR   ChiTaRS; NRIP3; human.
DR   GenomeRNAi; 56675; -.
DR   Pharos; Q9NQ35; Tdark.
DR   PRO; PR:Q9NQ35; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9NQ35; protein.
DR   Bgee; ENSG00000175352; Expressed in lateral nuclear group of thalamus and 156 other tissues.
DR   ExpressionAtlas; Q9NQ35; baseline and differential.
DR   Genevisible; Q9NQ35; HS.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05480; NRIP_C; 1.
DR   Gene3D; 2.40.70.10; -; 1.
DR   InterPro; IPR033821; NRIP_C.
DR   InterPro; IPR019103; Peptidase_aspartic_DDI1-type.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   Pfam; PF09668; Asp_protease; 1.
DR   SUPFAM; SSF50630; SSF50630; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..241
FT                   /note="Nuclear receptor-interacting protein 3"
FT                   /id="PRO_0000057953"
SQ   SEQUENCE   241 AA;  26975 MW;  3ECFE6A3CE3DB539 CRC64;
     MFYSGLLTEG GRKETDMREA ASLRQQRRMK QAVQFIHKDS ADLLPLDGLK KLGSSKDMQP
     HNILQRRLME TNLSKLRSGP RVPWASKTNK LNQAKSEGLK KSEEDDMILV SCQCAGKDVK
     ALVDTGCLYN LISLACVDRL GLKEHVKSHK HEGEKLSLPR HLKVVGQIEH LVITLGSLRL
     DCPAAVVDDN EKNLSLGLQT LRSLKCIINL DKHRLIMGKT DKEEIPFVET VSLNEDNTSE
     A