ID   NRM1_SCHPO              Reviewed;         342 AA.
AC   O42913;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Transcription factor nrm1;
DE   AltName: Full=Negative regulator of MBF targets 1;
GN   Name=nrm1; ORFNames=SPBC16A3.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION IN THE MBF COMPLEX, AND FUNCTION.
RX   PubMed=16916637; DOI=10.1016/j.molcel.2006.06.025;
RA   de Bruin R.A.M., Kalashnikova T.I., Chahwan C., McDonald W.H.,
RA   Wohlschlegel J., Yates J. III, Russell P., Wittenberg C.;
RT   "Constraining G1-specific transcription to late G1 phase: the MBF-
RT   associated corepressor Nrm1 acts via negative feedback.";
RL   Mol. Cell 23:483-496(2006).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Negative regulatory component of the MBF complex involved in
CC       cell-cycle-dependent transcription. {ECO:0000269|PubMed:16916637}.
CC   -!- SUBUNIT: Component of the MBF transcription factor complex.
CC       {ECO:0000269|PubMed:16916637}.
CC   -!- INTERACTION:
CC       O42913; Q09170: cds1; NbExp=2; IntAct=EBI-15720278, EBI-3650524;
CC       O42913; P41412: res2; NbExp=2; IntAct=EBI-15720278, EBI-1149177;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the WHI5/NRM1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA16858.1; -; Genomic_DNA.
DR   PIR; T39545; T39545.
DR   RefSeq; NP_596782.1; NM_001023803.2.
DR   AlphaFoldDB; O42913; -.
DR   BioGRID; 276289; 169.
DR   DIP; DIP-46173N; -.
DR   IntAct; O42913; 3.
DR   STRING; 4896.SPBC16A3.07c.1; -.
DR   iPTMnet; O42913; -.
DR   MaxQB; O42913; -.
DR   PaxDb; O42913; -.
DR   PRIDE; O42913; -.
DR   EnsemblFungi; SPBC16A3.07c.1; SPBC16A3.07c.1:pep; SPBC16A3.07c.
DR   GeneID; 2539737; -.
DR   KEGG; spo:SPBC16A3.07c; -.
DR   PomBase; SPBC16A3.07c; nrm1.
DR   VEuPathDB; FungiDB:SPBC16A3.07c; -.
DR   HOGENOM; CLU_811717_0_0_1; -.
DR   OMA; HGKLTRS; -.
DR   PRO; PR:O42913; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0000785; C:chromatin; IDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0003714; F:transcription corepressor activity; IMP:PomBase.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:PomBase.
DR   GO; GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; IMP:PomBase.
DR   InterPro; IPR013734; TF_Nrm1/Whi5.
DR   Pfam; PF08528; Whi5; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Transcription factor nrm1"
FT                   /id="PRO_0000352812"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..222
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   342 AA;  38328 MW;  783CD47C85CD9D75 CRC64;
     MDRSMEPLTP SRLNTLGERP TNEVYEYGKG KNVQHLFPIT PMQRPLGKEN AAPGTISPIA
     VRSRNVRAVE IADENACEEP VLKIKSVSST ESEEEKESST EIGEKQEKET HLEPKTPVQT
     NTNNNHLDDI QCCAKNLRLR LELAMYKVQV NQTFSPLQDL PIVAKTKLHN CPNSEPVTSI
     WNQRSLSSGK PPSLHLSGNR RLSMGSPTKS IYDQNGLTTP RPIGSDDLTH MYDPYTSPLR
     TPSRTLSRSS SHYLWVRHGK LTRSVSLLQH KTPRRIRPKS LSKSNSTPLK HLSAQKPNSN
     YYTGPPTPVS ISNTPENIHP SSSEVRRIAS HSKQFSDYGL IR