NRM_DANRE
ID NRM_DANRE Reviewed; 275 AA.
AC Q1L911;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Nurim;
DE AltName: Full=Nuclear envelope membrane protein;
DE AltName: Full=Nuclear rim protein;
GN Name=nrm; ORFNames=si:dkey-263h23.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nurim family. {ECO:0000305}.
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DR EMBL; CR391989; CAK10878.1; -; Genomic_DNA.
DR RefSeq; NP_001038660.1; NM_001045195.1.
DR AlphaFoldDB; Q1L911; -.
DR STRING; 7955.ENSDARP00000087736; -.
DR PaxDb; Q1L911; -.
DR Ensembl; ENSDART00000093304; ENSDARP00000087736; ENSDARG00000063690.
DR GeneID; 570027; -.
DR KEGG; dre:570027; -.
DR CTD; 11270; -.
DR ZFIN; ZDB-GENE-060503-445; nrm.
DR eggNOG; ENOG502RS62; Eukaryota.
DR GeneTree; ENSGT00390000008146; -.
DR HOGENOM; CLU_083708_1_0_1; -.
DR InParanoid; Q1L911; -.
DR OMA; WSIWFPL; -.
DR OrthoDB; 1048330at2759; -.
DR PhylomeDB; Q1L911; -.
DR TreeFam; TF324853; -.
DR PRO; PR:Q1L911; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000063690; Expressed in granulocyte and 18 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IBA:GO_Central.
DR InterPro; IPR033580; Nurim-like.
DR PANTHER; PTHR31040; PTHR31040; 1.
PE 3: Inferred from homology;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..275
FT /note="Nurim"
FT /id="PRO_0000299401"
FT TOPO_DOM 1..4
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..63
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..102
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..196
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..221
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..275
FT /note="Nuclear"
FT /evidence="ECO:0000255"
SQ SEQUENCE 275 AA; 31181 MW; C24219341ED81050 CRC64;
MASVTFRDGF LCVSALITFV FVFVTGADFV RFVSFRAINH NLSGAAPLCR DSVPWSVALR
DGVVQKAVAV DVLLLVVFSL QHSLLAWTPV KRVCQSVFGV LSRSVYCFTT AAALQILMHY
WRPVTSAPCL WSVSSAPWEI WFPLICFIVH FLCWAIICSI LLIFDYPELL GIKQVYYECL
GLGDPLLLKS ERAQRLYSHL RHPVCVELLT VLWLLPSFPL DRLLLAVFLT VYLILAHSLD
KQDCAYLRHQ LRNKLQLFST PLEGSEQTND NNKLE
