NRM_DROME
ID NRM_DROME Reviewed; 253 AA.
AC Q9VEG9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Nurim homolog;
DE AltName: Full=Nuclear envelope membrane protein;
DE AltName: Full=Nuclear rim protein;
GN Name=nrm; ORFNames=CG7655;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nurim family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55455.1; -; Genomic_DNA.
DR EMBL; AY060774; AAL28322.1; -; mRNA.
DR EMBL; BT003593; AAO39596.1; -; mRNA.
DR RefSeq; NP_650646.1; NM_142389.3.
DR AlphaFoldDB; Q9VEG9; -.
DR BioGRID; 67160; 5.
DR IntAct; Q9VEG9; 5.
DR STRING; 7227.FBpp0082912; -.
DR PaxDb; Q9VEG9; -.
DR PRIDE; Q9VEG9; -.
DR DNASU; 42128; -.
DR EnsemblMetazoa; FBtr0083479; FBpp0082912; FBgn0038536.
DR GeneID; 42128; -.
DR KEGG; dme:Dmel_CG7655; -.
DR UCSC; CG7655-RA; d. melanogaster.
DR FlyBase; FBgn0038536; CG7655.
DR VEuPathDB; VectorBase:FBgn0038536; -.
DR eggNOG; ENOG502RS62; Eukaryota.
DR GeneTree; ENSGT00390000008146; -.
DR HOGENOM; CLU_083708_0_0_1; -.
DR InParanoid; Q9VEG9; -.
DR OMA; WSIWFPL; -.
DR OrthoDB; 1048330at2759; -.
DR PhylomeDB; Q9VEG9; -.
DR BioGRID-ORCS; 42128; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42128; -.
DR PRO; PR:Q9VEG9; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038536; Expressed in oviduct (Drosophila) and 34 other tissues.
DR Genevisible; Q9VEG9; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IBA:GO_Central.
DR InterPro; IPR033580; Nurim-like.
DR PANTHER; PTHR31040; PTHR31040; 1.
PE 2: Evidence at transcript level;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..253
FT /note="Nurim homolog"
FT /id="PRO_0000299403"
FT TOPO_DOM 1..2
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..56
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..96
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..132
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..188
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..213
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..253
FT /note="Nuclear"
FT /evidence="ECO:0000255"
SQ SEQUENCE 253 AA; 28570 MW; CE25BDC208DDA8D7 CRC64;
MTSIAKSIVL LASLATFAYS LYVVGSLMMF LSTPRSISKA HTWIFNLLDN KSRLQTAYGP
VVFDTLYLIG FIFQHSFLKS AVVKKLLAKL GLSGAERTIY SLTSSLCLHY LIVNWLPAQS
IVLWQIDVEQ SAPLWWTFVI THGICWVVIF GGSLVMDLPE LLGVKQAYYD LKAYGPPISY
KSGELRNLYA HVRHPSFVGL SVILFATNVM SVDRLVMALL LTTYMYLAWS TDQKDVAYQK
IQLQRKKLEL KAK
