ID   NRM_DROPS               Reviewed;         253 AA.
AC   Q296J9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Nurim homolog;
DE   AltName: Full=Nuclear envelope membrane protein;
DE   AltName: Full=Nuclear rim protein;
GN   Name=nrm; ORFNames=GA20505;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nurim family. {ECO:0000305}.
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DR   EMBL; CM000070; EAL28458.1; -; Genomic_DNA.
DR   RefSeq; XP_001359313.1; XM_001359276.3.
DR   AlphaFoldDB; Q296J9; -.
DR   STRING; 7237.FBpp0284382; -.
DR   EnsemblMetazoa; FBtr0285944; FBpp0284382; FBgn0080499.
DR   GeneID; 4802384; -.
DR   KEGG; dpo:Dpse_GA20505; -.
DR   eggNOG; ENOG502RS62; Eukaryota.
DR   HOGENOM; CLU_083708_0_0_1; -.
DR   InParanoid; Q296J9; -.
DR   OMA; WSIWFPL; -.
DR   PhylomeDB; Q296J9; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0080499; Expressed in insect adult head and 2 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR033580; Nurim-like.
DR   PANTHER; PTHR31040; PTHR31040; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..253
FT                   /note="Nurim homolog"
FT                   /id="PRO_0000299404"
FT   TOPO_DOM        1..2
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..56
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..96
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..132
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..188
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        208..213
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..253
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   253 AA;  28888 MW;  C10728D6403659A5 CRC64;
     MATFAKVMLL LSSVATFGYT FFVVGKLMLF LSTPRSISKA HTWIFNLLDN KSRLETAYGP
     IVFDTLYLIG FIFQHSFLKS ALVKNLWRKL GLAAAERTIY SLTSSICLHY LLKNWLPAQS
     IVLWQVDVDE SAPLWWTFVV THGLGWAVIF GGSLIMDLPE LLGVKQVYYD LKEYGEPVAY
     KSSELRNLYS HVRHPSFVGL SVILFATNVM SLDRLLLASL LTVYMYVAWS TDDKDVAYQK
     QQLRNKKHEL KAQ