NRM_HUMAN
ID NRM_HUMAN Reviewed; 262 AA.
AC Q8IXM6; B0S7R0; B0S7R1; I3XIE2; I3XIE3; Q5JP57; Q5JP58; Q5JP59; Q5JP60;
AC Q8WU45; Q9BSX3; Q9UN92;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Nurim;
DE AltName: Full=Nuclear envelope membrane protein;
DE AltName: Full=Nuclear rim protein;
GN Name=NRM; Synonyms=NRM29; ORFNames=UNQ555/PRO1112;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), AND SUBCELLULAR LOCATION.
RX PubMed=23092226; DOI=10.2174/156652412803833571;
RA Chen H., Chen K., Chen J., Cheng H., Zhou R.;
RT "The integral nuclear membrane protein nurim plays a role in the
RT suppression of apoptosis.";
RL Curr. Mol. Med. 12:1372-1382(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Peripheral blood leukocyte;
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Ovary, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-262 (ISOFORM 1), AND SUBCELLULAR LOCATION.
RX PubMed=10402458; DOI=10.1083/jcb.146.1.29;
RA Rolls M.M., Stein P.A., Taylor S.S., Ha E., McKeon F., Rapoport T.A.;
RT "A visual screen of a GFP-fusion library identifies a new type of nuclear
RT envelope membrane protein.";
RL J. Cell Biol. 146:29-44(1999).
RN [9]
RP SUBCELLULAR LOCATION, AND MEMBRANE TOPOLOGY.
RX PubMed=15542857; DOI=10.1074/jbc.m410504200;
RA Hofemeister H., O'Hare P.;
RT "Analysis of the localization and topology of nurim, a polytopic protein
RT tightly associated with the inner nuclear membrane.";
RL J. Biol. Chem. 280:2512-2521(2005).
CC -!- INTERACTION:
CC Q8IXM6; Q8TD06: AGR3; NbExp=3; IntAct=EBI-10262547, EBI-3925742;
CC Q8IXM6; P16157-17: ANK1; NbExp=3; IntAct=EBI-10262547, EBI-941819;
CC Q8IXM6; P41181: AQP2; NbExp=3; IntAct=EBI-10262547, EBI-12701138;
CC Q8IXM6; Q13520: AQP6; NbExp=3; IntAct=EBI-10262547, EBI-13059134;
CC Q8IXM6; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10262547, EBI-11343438;
CC Q8IXM6; Q99437: ATP6V0B; NbExp=3; IntAct=EBI-10262547, EBI-3904417;
CC Q8IXM6; Q13323: BIK; NbExp=3; IntAct=EBI-10262547, EBI-700794;
CC Q8IXM6; P58418: CLRN1; NbExp=3; IntAct=EBI-10262547, EBI-17274839;
CC Q8IXM6; P34972: CNR2; NbExp=3; IntAct=EBI-10262547, EBI-2835940;
CC Q8IXM6; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10262547, EBI-18013275;
CC Q8IXM6; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-10262547, EBI-6942903;
CC Q8IXM6; P00387: CYB5R3; NbExp=3; IntAct=EBI-10262547, EBI-1046040;
CC Q8IXM6; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-10262547, EBI-2680384;
CC Q8IXM6; Q15125: EBP; NbExp=3; IntAct=EBI-10262547, EBI-3915253;
CC Q8IXM6; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10262547, EBI-781551;
CC Q8IXM6; P30040: ERP29; NbExp=3; IntAct=EBI-10262547, EBI-946830;
CC Q8IXM6; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10262547, EBI-18304435;
CC Q8IXM6; O15552: FFAR2; NbExp=3; IntAct=EBI-10262547, EBI-2833872;
CC Q8IXM6; A2A2Y4: FRMD3; NbExp=3; IntAct=EBI-10262547, EBI-6911547;
CC Q8IXM6; Q6ZVE7: GOLT1A; NbExp=3; IntAct=EBI-10262547, EBI-17231387;
CC Q8IXM6; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-10262547, EBI-3917143;
CC Q8IXM6; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-10262547, EBI-11955647;
CC Q8IXM6; O15529: GPR42; NbExp=3; IntAct=EBI-10262547, EBI-18076404;
CC Q8IXM6; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10262547, EBI-11721746;
CC Q8IXM6; Q96DB2: HDAC11; NbExp=3; IntAct=EBI-10262547, EBI-301713;
CC Q8IXM6; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-10262547, EBI-2867874;
CC Q8IXM6; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-10262547, EBI-18053395;
CC Q8IXM6; P43628: KIR2DL3; NbExp=3; IntAct=EBI-10262547, EBI-8632435;
CC Q8IXM6; O95214: LEPROTL1; NbExp=3; IntAct=EBI-10262547, EBI-750776;
CC Q8IXM6; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-10262547, EBI-11956541;
CC Q8IXM6; O14880: MGST3; NbExp=3; IntAct=EBI-10262547, EBI-724754;
CC Q8IXM6; Q6IN84: MRM1; NbExp=3; IntAct=EBI-10262547, EBI-5454865;
CC Q8IXM6; P04000: OPN1LW; NbExp=3; IntAct=EBI-10262547, EBI-13294781;
CC Q8IXM6; Q460N3-2: PARP15; NbExp=3; IntAct=EBI-10262547, EBI-17287327;
CC Q8IXM6; Q9Y5G9: PCDHGA4; NbExp=3; IntAct=EBI-10262547, EBI-12956949;
CC Q8IXM6; O00623: PEX12; NbExp=3; IntAct=EBI-10262547, EBI-594836;
CC Q8IXM6; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-10262547, EBI-10192441;
CC Q8IXM6; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-10262547, EBI-17589229;
CC Q8IXM6; Q96TC7: RMDN3; NbExp=3; IntAct=EBI-10262547, EBI-1056589;
CC Q8IXM6; O60930: RNASEH1; NbExp=3; IntAct=EBI-10262547, EBI-2372399;
CC Q8IXM6; Q96DX8: RTP4; NbExp=3; IntAct=EBI-10262547, EBI-12275482;
CC Q8IXM6; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-10262547, EBI-3920694;
CC Q8IXM6; Q12908: SLC10A2; NbExp=3; IntAct=EBI-10262547, EBI-18114847;
CC Q8IXM6; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-10262547, EBI-18159983;
CC Q8IXM6; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-10262547, EBI-17595455;
CC Q8IXM6; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-10262547, EBI-8644112;
CC Q8IXM6; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-10262547, EBI-17295964;
CC Q8IXM6; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-10262547, EBI-12898013;
CC Q8IXM6; Q9H2J7: SLC6A15; NbExp=3; IntAct=EBI-10262547, EBI-11343466;
CC Q8IXM6; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-10262547, EBI-10819434;
CC Q8IXM6; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10262547, EBI-17280858;
CC Q8IXM6; Q16623: STX1A; NbExp=3; IntAct=EBI-10262547, EBI-712466;
CC Q8IXM6; Q9UH99: SUN2; NbExp=3; IntAct=EBI-10262547, EBI-1044964;
CC Q8IXM6; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-10262547, EBI-18178701;
CC Q8IXM6; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10262547, EBI-6447886;
CC Q8IXM6; Q8IWR1: TRIM59; NbExp=7; IntAct=EBI-10262547, EBI-10262539;
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000269|PubMed:10402458, ECO:0000269|PubMed:15542857,
CC ECO:0000269|PubMed:23092226}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:10402458, ECO:0000269|PubMed:15542857,
CC ECO:0000269|PubMed:23092226}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=a;
CC IsoId=Q8IXM6-1; Sequence=Displayed;
CC Name=2; Synonyms=b;
CC IsoId=Q8IXM6-2; Sequence=VSP_027627;
CC Name=3; Synonyms=c;
CC IsoId=Q8IXM6-6; Sequence=VSP_054311, VSP_054312;
CC -!- SIMILARITY: Belongs to the nurim family. {ECO:0000305}.
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DR EMBL; JQ798186; AFL55648.1; -; mRNA.
DR EMBL; JQ798187; AFL55649.1; -; mRNA.
DR EMBL; AY358411; AAQ88777.1; -; mRNA.
DR EMBL; AK315190; BAG37630.1; -; mRNA.
DR EMBL; AB110935; BAD13701.1; -; Genomic_DNA.
DR EMBL; AB110936; BAD13702.1; -; Genomic_DNA.
DR EMBL; AB202096; BAE78616.1; -; Genomic_DNA.
DR EMBL; AL662797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL732442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL845353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX908728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR788240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03320.1; -; Genomic_DNA.
DR EMBL; BC004509; AAH04509.2; -; mRNA.
DR EMBL; BC021260; AAH21260.1; -; mRNA.
DR EMBL; BC039865; AAH39865.1; -; mRNA.
DR EMBL; AF143676; AAD45885.1; -; mRNA.
DR CCDS; CCDS4686.1; -. [Q8IXM6-1]
DR CCDS; CCDS59498.1; -. [Q8IXM6-2]
DR RefSeq; NP_001257636.1; NM_001270707.1.
DR RefSeq; NP_001257637.1; NM_001270708.1.
DR RefSeq; NP_001257638.1; NM_001270709.1. [Q8IXM6-2]
DR RefSeq; NP_001257639.1; NM_001270710.1. [Q8IXM6-6]
DR RefSeq; NP_009174.1; NM_007243.2. [Q8IXM6-1]
DR AlphaFoldDB; Q8IXM6; -.
DR BioGRID; 116427; 69.
DR IntAct; Q8IXM6; 60.
DR STRING; 9606.ENSP00000259953; -.
DR iPTMnet; Q8IXM6; -.
DR PhosphoSitePlus; Q8IXM6; -.
DR SwissPalm; Q8IXM6; -.
DR BioMuta; NRM; -.
DR DMDM; 74750736; -.
DR EPD; Q8IXM6; -.
DR jPOST; Q8IXM6; -.
DR MassIVE; Q8IXM6; -.
DR MaxQB; Q8IXM6; -.
DR PaxDb; Q8IXM6; -.
DR PeptideAtlas; Q8IXM6; -.
DR PRIDE; Q8IXM6; -.
DR ProteomicsDB; 71030; -. [Q8IXM6-1]
DR ProteomicsDB; 71031; -. [Q8IXM6-2]
DR Antibodypedia; 26491; 53 antibodies from 17 providers.
DR DNASU; 11270; -.
DR Ensembl; ENST00000259953.8; ENSP00000259953.4; ENSG00000137404.15. [Q8IXM6-1]
DR Ensembl; ENST00000376420.9; ENSP00000365602.5; ENSG00000137404.15. [Q8IXM6-2]
DR Ensembl; ENST00000376421.7; ENSP00000365603.5; ENSG00000137404.15. [Q8IXM6-1]
DR Ensembl; ENST00000383570.8; ENSP00000373064.4; ENSG00000206484.10. [Q8IXM6-2]
DR Ensembl; ENST00000383571.6; ENSP00000373065.2; ENSG00000206484.10. [Q8IXM6-1]
DR Ensembl; ENST00000422181.5; ENSP00000409285.1; ENSG00000234809.8. [Q8IXM6-1]
DR Ensembl; ENST00000422664.6; ENSP00000394788.2; ENSG00000228854.8. [Q8IXM6-2]
DR Ensembl; ENST00000422747.5; ENSP00000414927.1; ENSG00000236843.8. [Q8IXM6-1]
DR Ensembl; ENST00000427944.5; ENSP00000405789.1; ENSG00000228854.8. [Q8IXM6-1]
DR Ensembl; ENST00000431322.5; ENSP00000398752.1; ENSG00000228867.8. [Q8IXM6-1]
DR Ensembl; ENST00000438502.5; ENSP00000397755.1; ENSG00000235773.8. [Q8IXM6-1]
DR Ensembl; ENST00000445058.6; ENSP00000389958.2; ENSG00000236843.8. [Q8IXM6-2]
DR Ensembl; ENST00000449041.6; ENSP00000399560.2; ENSG00000228867.8. [Q8IXM6-2]
DR Ensembl; ENST00000450138.6; ENSP00000407111.2; ENSG00000234809.8. [Q8IXM6-2]
DR Ensembl; ENST00000456720.6; ENSP00000392502.2; ENSG00000235773.8. [Q8IXM6-2]
DR Ensembl; ENST00000610775.1; ENSP00000481407.1; ENSG00000228867.8. [Q8IXM6-1]
DR Ensembl; ENST00000612190.1; ENSP00000482593.1; ENSG00000234809.8. [Q8IXM6-1]
DR Ensembl; ENST00000613827.1; ENSP00000481406.1; ENSG00000228854.8. [Q8IXM6-1]
DR Ensembl; ENST00000617159.1; ENSP00000478812.1; ENSG00000236843.8. [Q8IXM6-1]
DR Ensembl; ENST00000617220.1; ENSP00000483875.1; ENSG00000206484.10. [Q8IXM6-1]
DR Ensembl; ENST00000620249.1; ENSP00000482740.1; ENSG00000235773.8. [Q8IXM6-1]
DR GeneID; 11270; -.
DR KEGG; hsa:11270; -.
DR MANE-Select; ENST00000376421.7; ENSP00000365603.5; NM_001384369.1; NP_001371298.1.
DR UCSC; uc003nrc.4; human. [Q8IXM6-1]
DR CTD; 11270; -.
DR DisGeNET; 11270; -.
DR GeneCards; NRM; -.
DR HGNC; HGNC:8003; NRM.
DR HPA; ENSG00000137404; Low tissue specificity.
DR neXtProt; NX_Q8IXM6; -.
DR OpenTargets; ENSG00000137404; -.
DR PharmGKB; PA31782; -.
DR VEuPathDB; HostDB:ENSG00000137404; -.
DR eggNOG; ENOG502RS62; Eukaryota.
DR GeneTree; ENSGT00390000008146; -.
DR HOGENOM; CLU_083708_1_1_1; -.
DR InParanoid; Q8IXM6; -.
DR OMA; WSIWFPL; -.
DR OrthoDB; 1048330at2759; -.
DR PhylomeDB; Q8IXM6; -.
DR TreeFam; TF324853; -.
DR PathwayCommons; Q8IXM6; -.
DR SignaLink; Q8IXM6; -.
DR BioGRID-ORCS; 11270; 13 hits in 1077 CRISPR screens.
DR ChiTaRS; NRM; human.
DR GenomeRNAi; 11270; -.
DR Pharos; Q8IXM6; Tbio.
DR PRO; PR:Q8IXM6; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8IXM6; protein.
DR Bgee; ENSG00000137404; Expressed in ganglionic eminence and 96 other tissues.
DR ExpressionAtlas; Q8IXM6; baseline and differential.
DR Genevisible; Q8IXM6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005635; C:nuclear envelope; IDA:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IDA:HPA.
DR InterPro; IPR033580; Nurim-like.
DR PANTHER; PTHR31040; PTHR31040; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..262
FT /note="Nurim"
FT /id="PRO_0000299395"
FT TOPO_DOM 1..4
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..58
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..97
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..133
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..191
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..216
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..262
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT VAR_SEQ 45..109
FT /note="DARQGWLAALQDRSILAPLAWDLGLLLLFVGQHSLMAAERVKAWTSRYFGVL
FT QRSLYVACTALAL -> GILPCAGAGRASGPEVSPGSQTLLPPAPPSVCGAADSAVGGA
FT YPGHGPSPPCFPPYPLPGPGSRA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:23092226"
FT /id="VSP_054311"
FT VAR_SEQ 110..262
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:23092226"
FT /id="VSP_054312"
FT VAR_SEQ 110..168
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:23092226"
FT /id="VSP_027627"
SQ SEQUENCE 262 AA; 29379 MW; 47ED52384BE6C299 CRC64;
MAPALLLIPA ALASFILAFG TGVEFVRFTS LRPLLGGIPE SGGPDARQGW LAALQDRSIL
APLAWDLGLL LLFVGQHSLM AAERVKAWTS RYFGVLQRSL YVACTALALQ LVMRYWEPIP
KGPVLWEARA EPWATWVPLL CFVLHVISWL LIFSILLVFD YAELMGLKQV YYHVLGLGEP
LALKSPRALR LFSHLRHPVC VELLTVLWVV PTLGTDRLLL AFLLTLYLGL AHGLDQQDLR
YLRAQLQRKL HLLSRPQDGE AE
