NRM_MOUSE
ID NRM_MOUSE Reviewed; 262 AA.
AC Q8VC65;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Nurim;
DE AltName: Full=Nuclear envelope membrane protein;
DE AltName: Full=Nuclear rim protein;
GN Name=Nrm;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nurim family. {ECO:0000305}.
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DR EMBL; BC021750; AAH21750.1; -; mRNA.
DR EMBL; BC026576; AAH26576.1; -; mRNA.
DR CCDS; CCDS28708.1; -.
DR RefSeq; NP_598883.1; NM_134122.2.
DR AlphaFoldDB; Q8VC65; -.
DR BioGRID; 223084; 1.
DR STRING; 10090.ENSMUSP00000073873; -.
DR iPTMnet; Q8VC65; -.
DR PhosphoSitePlus; Q8VC65; -.
DR SwissPalm; Q8VC65; -.
DR EPD; Q8VC65; -.
DR MaxQB; Q8VC65; -.
DR PaxDb; Q8VC65; -.
DR PeptideAtlas; Q8VC65; -.
DR PRIDE; Q8VC65; -.
DR ProteomicsDB; 293735; -.
DR Antibodypedia; 26491; 53 antibodies from 17 providers.
DR DNASU; 106582; -.
DR Ensembl; ENSMUST00000074259; ENSMUSP00000073873; ENSMUSG00000059791.
DR GeneID; 106582; -.
DR KEGG; mmu:106582; -.
DR UCSC; uc008cis.1; mouse.
DR CTD; 11270; -.
DR MGI; MGI:2146855; Nrm.
DR VEuPathDB; HostDB:ENSMUSG00000059791; -.
DR eggNOG; ENOG502RS62; Eukaryota.
DR GeneTree; ENSGT00390000008146; -.
DR HOGENOM; CLU_083708_1_0_1; -.
DR InParanoid; Q8VC65; -.
DR OMA; WSIWFPL; -.
DR OrthoDB; 1048330at2759; -.
DR PhylomeDB; Q8VC65; -.
DR TreeFam; TF324853; -.
DR BioGRID-ORCS; 106582; 5 hits in 75 CRISPR screens.
DR ChiTaRS; Nrm; mouse.
DR PRO; PR:Q8VC65; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8VC65; protein.
DR Bgee; ENSMUSG00000059791; Expressed in spermatid and 180 other tissues.
DR ExpressionAtlas; Q8VC65; baseline and differential.
DR Genevisible; Q8VC65; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; TAS:MGI.
DR GO; GO:0005652; C:nuclear lamina; TAS:MGI.
DR GO; GO:0031965; C:nuclear membrane; ISO:MGI.
DR InterPro; IPR033580; Nurim-like.
DR PANTHER; PTHR31040; PTHR31040; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..262
FT /note="Nurim"
FT /id="PRO_0000299397"
FT TOPO_DOM 1..4
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..58
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..97
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..133
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..191
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..216
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..262
FT /note="Nuclear"
FT /evidence="ECO:0000255"
SQ SEQUENCE 262 AA; 29435 MW; 44FCA354D43589FF CRC64;
MAPALLLVPA ALASFILAFG TGVEFVRFTS LRPLLGGIPE SGGPDARHGW LAALQDRSIL
ASLAWDLCLL LLFVVQHSLM ATEAVKAWTS RYFGVLQRSL YVACTALALQ LVMRYWETTP
RGPVLWEARA EPWATWVPLL CFVLHVVSWL LIFSILLVFD YAELMGLKQV YYHVLGLGEP
LSLKSPRALR LFSHLRHPVC VELLTVLWVV PTLGTDRLLL ALLFTLYLGL AHGLDQQDLR
YLRSQLQRKL HLLSRPQDGE AE
