ID   NRM_PANTR               Reviewed;         262 AA.
AC   Q1XHX8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Nurim;
DE   AltName: Full=Nuclear envelope membrane protein;
DE   AltName: Full=Nuclear rim protein;
GN   Name=NRM;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA   Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA   Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA   Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA   Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA   Inoko H., Bahram S.;
RT   "Rapid evolution of major histocompatibility complex class I genes in
RT   primates generates new disease alleles in humans via hitchhiking
RT   diversity.";
RL   Genetics 173:1555-1570(2006).
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nurim family. {ECO:0000305}.
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DR   EMBL; AB210177; BAE92791.1; -; Genomic_DNA.
DR   EMBL; AB210178; BAE92792.1; -; Genomic_DNA.
DR   RefSeq; NP_001035205.1; NM_001040116.1.
DR   AlphaFoldDB; Q1XHX8; -.
DR   STRING; 9598.ENSPTRP00000030602; -.
DR   PaxDb; Q1XHX8; -.
DR   Ensembl; ENSPTRT00000082276; ENSPTRP00000066973; ENSPTRG00000017937.
DR   GeneID; 471957; -.
DR   KEGG; ptr:471957; -.
DR   CTD; 11270; -.
DR   VGNC; VGNC:48899; NRM.
DR   eggNOG; ENOG502RS62; Eukaryota.
DR   GeneTree; ENSGT00390000008146; -.
DR   HOGENOM; CLU_083708_1_0_1; -.
DR   InParanoid; Q1XHX8; -.
DR   OMA; WSIWFPL; -.
DR   OrthoDB; 1048330at2759; -.
DR   TreeFam; TF324853; -.
DR   Proteomes; UP000002277; Chromosome 6.
DR   Bgee; ENSPTRG00000017937; Expressed in testis and 18 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IBA:GO_Central.
DR   InterPro; IPR033580; Nurim-like.
DR   PANTHER; PTHR31040; PTHR31040; 1.
PE   3: Inferred from homology;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..262
FT                   /note="Nurim"
FT                   /id="PRO_0000299398"
FT   TOPO_DOM        1..4
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        5..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..58
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..97
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..133
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..191
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..216
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..262
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   262 AA;  29365 MW;  47ED580B4BE6C53A CRC64;
     MAPALLLVPA ALASFILAFG TGVEFVRFTS LRPLLGGIPE SGGPDARQGW LAALQDRSIL
     APLAWDLGLL LLFVGQHSLM AAERVKAWTS RYFGVLQRSL YVACTALALQ LVMRYWEPIP
     KGPVLWEARA EPWATWVPLL CFVLHVISWL LIFSILLVFD YAELMGLKQV YYHVLGLGEP
     LALKSPRALR LFSHLRHPVC VELLTVLWVV PTLGTDRLLL AFLLTLYLGL AHGLDQQDLR
     YLRAQLQRKL HLLSRPQDGE AE