ID   NRN1A_XENLA             Reviewed;         144 AA.
AC   Q90ZM9; Q63ZL9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Neuritin-A;
DE   AltName: Full=Candidate plasticity gene 15 protein;
DE   Flags: Precursor;
GN   Name=nrn1-a; Synonyms=cpg15;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Brain;
RX   PubMed=11406826; DOI=10.1002/cne.1044;
RA   Nedivi E., Javaherian A., Cantallops I., Cline H.T.;
RT   "Developmental regulation of CPG15 expression in Xenopus.";
RL   J. Comp. Neurol. 435:464-473(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates postsynaptic dendritic arbor elaboration and
CC       synaptic maturation. {ECO:0000269|PubMed:11406826}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in sensory regions of the brain including
CC       the visual, auditory and olfactory systems. Within the retina, only
CC       expressed in the retinal ganglion cells. Concentrated in axon tracts
CC       including retinal axons. {ECO:0000269|PubMed:11406826}.
CC   -!- DEVELOPMENTAL STAGE: First detected in the developing spinal cord and
CC       becomes widespread as development proceeds.
CC       {ECO:0000269|PubMed:11406826}.
CC   -!- SIMILARITY: Belongs to the neuritin family. {ECO:0000305}.
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DR   EMBL; AF378092; AAK55417.1; -; mRNA.
DR   EMBL; BC082893; AAH82893.1; -; mRNA.
DR   RefSeq; NP_001079157.1; NM_001085688.1.
DR   AlphaFoldDB; Q90ZM9; -.
DR   DNASU; 373709; -.
DR   GeneID; 373709; -.
DR   KEGG; xla:373709; -.
DR   CTD; 373709; -.
DR   Xenbase; XB-GENE-6252721; nrn1.S.
DR   OrthoDB; 1469106at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 373709; Expressed in brain and 3 other tissues.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   InterPro; IPR026144; Neuritin_fam.
DR   PANTHER; PTHR15902; PTHR15902; 1.
DR   Pfam; PF15056; NRN1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..114
FT                   /note="Neuritin-A"
FT                   /id="PRO_0000262520"
FT   PROPEP          115..144
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000262521"
FT   LIPID           114
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        141
FT                   /note="L -> W (in Ref. 2; AAH82893)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   144 AA;  15889 MW;  2D90FADC5285807F CRC64;
     MGLKLSGRYI FLVLAVHLAY LLQAVKATGK CDAVFKGLSD CMLTLGDKVA NYPQDLEEKK
     NLDTICSYWD DFHVCTVTAL ADCQEGAADI WEKLKRQSKN LNIQGSLFEL CPGSAGAPGQ
     RLLFPAFLPL LMVFLSTLFI LVLQ