NRN1L_HUMAN
ID NRN1L_HUMAN Reviewed; 165 AA.
AC Q496H8; Q6UWH7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Neuritin-like protein;
DE Flags: Precursor;
GN Name=NRN1L; ORFNames=UNQ2446/PRO5725;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q496H8; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-13079132, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the neuritin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY358782; AAQ89142.1; -; mRNA.
DR EMBL; CH471092; EAW83184.1; -; Genomic_DNA.
DR EMBL; BC100863; AAI00864.1; -; mRNA.
DR EMBL; BC100864; AAI00865.1; -; mRNA.
DR EMBL; BC100865; AAI00866.1; -; mRNA.
DR EMBL; BC100866; AAI00867.1; -; mRNA.
DR CCDS; CCDS10850.1; -.
DR RefSeq; NP_001335611.1; NM_001348682.1.
DR RefSeq; NP_940845.1; NM_198443.1.
DR AlphaFoldDB; Q496H8; -.
DR SMR; Q496H8; -.
DR BioGRID; 125843; 4.
DR IntAct; Q496H8; 1.
DR STRING; 9606.ENSP00000342411; -.
DR BioMuta; NRN1L; -.
DR DMDM; 172046108; -.
DR PaxDb; Q496H8; -.
DR PeptideAtlas; Q496H8; -.
DR PRIDE; Q496H8; -.
DR Antibodypedia; 49763; 100 antibodies from 17 providers.
DR DNASU; 123904; -.
DR Ensembl; ENST00000339176.8; ENSP00000342411.3; ENSG00000188038.8.
DR GeneID; 123904; -.
DR KEGG; hsa:123904; -.
DR MANE-Select; ENST00000339176.8; ENSP00000342411.3; NM_198443.2; NP_940845.1.
DR UCSC; uc002euu.4; human.
DR CTD; 123904; -.
DR DisGeNET; 123904; -.
DR GeneCards; NRN1L; -.
DR HGNC; HGNC:29811; NRN1L.
DR HPA; ENSG00000188038; Low tissue specificity.
DR neXtProt; NX_Q496H8; -.
DR PharmGKB; PA162398187; -.
DR VEuPathDB; HostDB:ENSG00000188038; -.
DR eggNOG; ENOG502S3XG; Eukaryota.
DR GeneTree; ENSGT00530000063853; -.
DR HOGENOM; CLU_133886_0_0_1; -.
DR InParanoid; Q496H8; -.
DR OMA; FHACASQ; -.
DR OrthoDB; 1469106at2759; -.
DR PhylomeDB; Q496H8; -.
DR TreeFam; TF332589; -.
DR PathwayCommons; Q496H8; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; Q496H8; -.
DR BioGRID-ORCS; 123904; 15 hits in 1066 CRISPR screens.
DR GenomeRNAi; 123904; -.
DR Pharos; Q496H8; Tdark.
DR PRO; PR:Q496H8; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q496H8; protein.
DR Bgee; ENSG00000188038; Expressed in putamen and 91 other tissues.
DR ExpressionAtlas; Q496H8; baseline and differential.
DR GO; GO:0046658; C:anchored component of plasma membrane; IBA:GO_Central.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:1990138; P:neuron projection extension; IBA:GO_Central.
DR InterPro; IPR026144; Neuritin_fam.
DR PANTHER; PTHR15902; PTHR15902; 1.
DR Pfam; PF15056; NRN1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..139
FT /note="Neuritin-like protein"
FT /id="PRO_0000319429"
FT PROPEP 140..165
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000319430"
FT LIPID 139
FT /note="GPI-anchor amidated alanine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 165 AA; 17786 MW; 455BD71ADEB6F0CC CRC64;
MMRCCRRRCC CRQPPHALRP LLLLPLVLLP PLAAAAAGPN RCDTIYQGFA ECLIRLGDSM
GRGGELETIC RSWNDFHACA SQVLSGCPEE AAAVWESLQQ EARQAPRPNN LHTLCGAPVH
VRERGTGSET NQETLRATAP ALPMAPAPPL LAAALALAYL LRPLA
