NRN1L_MOUSE
ID NRN1L_MOUSE Reviewed; 162 AA.
AC Q8C4W3; Q8BN06;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Neuritin-like protein;
DE AltName: Full=Candidate plasticity gene 15-2 protein;
DE Flags: Precursor;
GN Name=Nrn1l; Synonyms=Cpg15-2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=18265009; DOI=10.1002/cne.21649;
RA Fujino T., Wu Z., Lin W.C., Phillips M.A., Nedivi E.;
RT "cpg15 and cpg15-2 constitute a family of activity-regulated ligands
RT expressed differentially in the nervous system to promote neurite growth
RT and neuronal survival.";
RL J. Comp. Neurol. 507:1831-1845(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Ovary, Retina, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Oocyte;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C4W3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C4W3-2; Sequence=VSP_031481;
CC -!- SIMILARITY: Belongs to the neuritin family. {ECO:0000305}.
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DR EMBL; DQ176852; ABA55711.1; -; mRNA.
DR EMBL; AK080711; BAC37986.1; -; mRNA.
DR EMBL; AK090312; BAC41165.1; -; mRNA.
DR EMBL; BC100315; AAI00316.1; -; mRNA.
DR CCDS; CCDS22618.1; -. [Q8C4W3-1]
DR CCDS; CCDS80924.1; -. [Q8C4W3-2]
DR RefSeq; NP_001288103.1; NM_001301174.1. [Q8C4W3-2]
DR RefSeq; NP_778189.1; NM_175024.4. [Q8C4W3-1]
DR AlphaFoldDB; Q8C4W3; -.
DR STRING; 10090.ENSMUSP00000056940; -.
DR PaxDb; Q8C4W3; -.
DR PRIDE; Q8C4W3; -.
DR ProteomicsDB; 293736; -. [Q8C4W3-1]
DR ProteomicsDB; 293737; -. [Q8C4W3-2]
DR Antibodypedia; 49763; 100 antibodies from 17 providers.
DR DNASU; 234700; -.
DR Ensembl; ENSMUST00000060167; ENSMUSP00000056940; ENSMUSG00000044287. [Q8C4W3-1]
DR Ensembl; ENSMUST00000118920; ENSMUSP00000113445; ENSMUSG00000044287. [Q8C4W3-2]
DR GeneID; 234700; -.
DR KEGG; mmu:234700; -.
DR UCSC; uc009nem.2; mouse. [Q8C4W3-1]
DR UCSC; uc012gjq.2; mouse. [Q8C4W3-2]
DR CTD; 123904; -.
DR MGI; MGI:2443642; Nrn1l.
DR VEuPathDB; HostDB:ENSMUSG00000044287; -.
DR eggNOG; ENOG502S3XG; Eukaryota.
DR GeneTree; ENSGT00530000063853; -.
DR HOGENOM; CLU_133886_0_0_1; -.
DR InParanoid; Q8C4W3; -.
DR OMA; FHACASQ; -.
DR OrthoDB; 1469106at2759; -.
DR PhylomeDB; Q8C4W3; -.
DR TreeFam; TF332589; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 234700; 3 hits in 70 CRISPR screens.
DR ChiTaRS; Nrn1l; mouse.
DR PRO; PR:Q8C4W3; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8C4W3; protein.
DR Bgee; ENSMUSG00000044287; Expressed in primary oocyte and 53 other tissues.
DR Genevisible; Q8C4W3; MM.
DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:MGI.
DR GO; GO:0030424; C:axon; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:1990138; P:neuron projection extension; IDA:MGI.
DR InterPro; IPR026144; Neuritin_fam.
DR PANTHER; PTHR15902; PTHR15902; 1.
DR Pfam; PF15056; NRN1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..136
FT /note="Neuritin-like protein"
FT /id="PRO_0000319431"
FT PROPEP 137..162
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000319432"
FT LIPID 136
FT /note="GPI-anchor amidated alanine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 30
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031481"
SQ SEQUENCE 162 AA; 17390 MW; 9380CE458A3B394F CRC64;
MMCNCCHCHW RRRCQRLPCA LTLLLLLPLA VASEGPNRCD TIYQGFAECL IRLGDGMGRG
GELQTVCRSW NDFHACASRV LSGCPEEAAA VWESLQQEAR RAPHPDNLHI LCGAPVSVRE
RIAGPETNQE TLRATAPALA PAPAPVLLAA ALALACLLGP LA
