NRN1_HUMAN
ID NRN1_HUMAN Reviewed; 142 AA.
AC Q9NPD7; B2RA93; Q7Z4Y1;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Neuritin;
DE Flags: Precursor;
GN Name=NRN1; Synonyms=NRN;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Adrenal cortex;
RX PubMed=9122250; DOI=10.1073/pnas.94.6.2648;
RA Naeve G.S., Ramakrishnan M., Kramer R., Hevroni D., Citri Y., Theill L.E.;
RT "Neuritin: a gene induced by neural activity and neurotrophins that
RT promotes neuritogenesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:2648-2653(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhou H., Huang X., Zhou Y., Hu S., Tang X., Yuan J., Qiang B.;
RT "Isolation and cloning of a novel human cDNA encoding rat neuritin
RT homolog.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Fan Y.X., Yu L., Zhang X.N., Xin Y.R., Wang X.K., Zhao S.Y.;
RT "Cloning of a novel human cDNA homologous to Rattus norvegicus neuritin
RT mRNA.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pericardium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Promotes neurite outgrowth and especially branching of
CC neuritic processes in primary hippocampal and cortical cells.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the outer core of AMPAR complex. AMPAR complex
CC consists of an inner core made of 4 pore-forming GluA/GRIA proteins
CC (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged
CC in a twofold symmetry. One of the two pairs of distinct binding sites
CC is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors
CC CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR
CC complex is complemented by outer core constituents binding directly to
CC the GluA/GRIA proteins at sites distinct from the interaction sites of
CC the inner core constituents. Outer core constituents include at least
CC PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the
CC inner and outer core serve as a platform for other, more peripherally
CC associated AMPAR constituents. Alone or in combination, these auxiliary
CC subunits control the gating and pharmacology of the AMPAR complex and
CC profoundly impact their biogenesis and protein processing (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}. Synapse {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neuritin family. {ECO:0000305}.
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DR EMBL; AF136631; AAF62371.1; -; mRNA.
DR EMBL; AF114833; AAP97232.1; -; mRNA.
DR EMBL; AL136307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK314095; BAG36790.1; -; mRNA.
DR EMBL; CH471087; EAW55184.1; -; Genomic_DNA.
DR EMBL; BC002683; AAH02683.1; -; mRNA.
DR EMBL; BC042019; AAH42019.1; -; mRNA.
DR CCDS; CCDS4495.1; -.
DR RefSeq; NP_001265639.1; NM_001278710.1.
DR RefSeq; NP_001265640.1; NM_001278711.1.
DR RefSeq; NP_057672.1; NM_016588.2.
DR AlphaFoldDB; Q9NPD7; -.
DR BioGRID; 119450; 39.
DR IntAct; Q9NPD7; 23.
DR STRING; 9606.ENSP00000480483; -.
DR iPTMnet; Q9NPD7; -.
DR PhosphoSitePlus; Q9NPD7; -.
DR BioMuta; NRN1; -.
DR MassIVE; Q9NPD7; -.
DR PaxDb; Q9NPD7; -.
DR PeptideAtlas; Q9NPD7; -.
DR PRIDE; Q9NPD7; -.
DR ProteomicsDB; 81975; -.
DR Antibodypedia; 24561; 195 antibodies from 31 providers.
DR DNASU; 51299; -.
DR Ensembl; ENST00000244766.7; ENSP00000244766.2; ENSG00000124785.9.
DR Ensembl; ENST00000616243.1; ENSP00000484055.1; ENSG00000124785.9.
DR GeneID; 51299; -.
DR KEGG; hsa:51299; -.
DR MANE-Select; ENST00000244766.7; ENSP00000244766.2; NM_016588.3; NP_057672.1.
DR UCSC; uc003mwu.4; human.
DR CTD; 51299; -.
DR DisGeNET; 51299; -.
DR GeneCards; NRN1; -.
DR HGNC; HGNC:17972; NRN1.
DR HPA; ENSG00000124785; Tissue enhanced (brain, parathyroid gland).
DR MIM; 607409; gene.
DR neXtProt; NX_Q9NPD7; -.
DR OpenTargets; ENSG00000124785; -.
DR PharmGKB; PA38477; -.
DR VEuPathDB; HostDB:ENSG00000124785; -.
DR eggNOG; ENOG502RZNR; Eukaryota.
DR GeneTree; ENSGT00530000063853; -.
DR HOGENOM; CLU_135101_0_0_1; -.
DR InParanoid; Q9NPD7; -.
DR OMA; KCDAVFR; -.
DR OrthoDB; 1469106at2759; -.
DR PhylomeDB; Q9NPD7; -.
DR TreeFam; TF332589; -.
DR PathwayCommons; Q9NPD7; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; Q9NPD7; -.
DR SIGNOR; Q9NPD7; -.
DR BioGRID-ORCS; 51299; 11 hits in 1071 CRISPR screens.
DR ChiTaRS; NRN1; human.
DR GenomeRNAi; 51299; -.
DR Pharos; Q9NPD7; Tbio.
DR PRO; PR:Q9NPD7; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9NPD7; protein.
DR Bgee; ENSG00000124785; Expressed in cerebellar cortex and 179 other tissues.
DR ExpressionAtlas; Q9NPD7; baseline and differential.
DR Genevisible; Q9NPD7; HS.
DR GO; GO:0046658; C:anchored component of plasma membrane; IBA:GO_Central.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:1990138; P:neuron projection extension; IBA:GO_Central.
DR InterPro; IPR026144; Neuritin_fam.
DR PANTHER; PTHR15902; PTHR15902; 1.
DR Pfam; PF15056; NRN1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal; Synapse.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..116
FT /note="Neuritin"
FT /id="PRO_0000262512"
FT PROPEP 117..142
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000262513"
FT LIPID 116
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CONFLICT 48..49
FT /note="SM -> TW (in Ref. 3; AAP97232)"
FT /evidence="ECO:0000305"
FT CONFLICT 55..56
FT /note="GL -> AW (in Ref. 3; AAP97232)"
FT /evidence="ECO:0000305"
FT CONFLICT 113..115
FT /note="SGN -> RAT (in Ref. 3; AAP97232)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 15333 MW; 6C3C3DAC8D6392E6 CRC64;
MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA NYPQGLDDKT
NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN LNIQGSLFEL CGSGNGAAGS
LLPAFPVLLV SLSAALATWL SF
