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NRPD7_ARATH
ID   NRPD7_ARATH             Reviewed;         174 AA.
AC   Q8LE42; Q9LIK8;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=DNA-directed RNA polymerase IV subunit 7;
GN   Name=NRPD7; OrderedLocusNames=At3g22900;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, AND NOMENCLATURE.
RX   PubMed=19110459; DOI=10.1016/j.molcel.2008.12.015;
RA   Ream T.S., Haag J.R., Wierzbicki A.T., Nicora C.D., Norbeck A.D., Zhu J.K.,
RA   Hagen G., Guilfoyle T.J., Pasa-Tolic L., Pikaard C.S.;
RT   "Subunit compositions of the RNA-silencing enzymes Pol IV and Pol V reveal
RT   their origins as specialized forms of RNA polymerase II.";
RL   Mol. Cell 33:192-203(2009).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH NRPD1, AND SUBUNIT.
RX   PubMed=21811420; DOI=10.1371/journal.pgen.1002195;
RA   Law J.A., Vashisht A.A., Wohlschlegel J.A., Jacobsen S.E.;
RT   "SHH1, a homeodomain protein required for DNA methylation, as well as RDR2,
RT   RDM4, and chromatin remodeling factors, associate with RNA polymerase IV.";
RL   PLoS Genet. 7:E1002195-E1002195(2011).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Component of RNA polymerase IV which mediates 24-nt short-interfering
CC       RNAs (siRNA) accumulation. Implicated in siRNA-directed heterochromatin
CC       formation through the action of DCL3 and AGO4, and subsequent DNA
CC       methylation-dependent silencing of targeted sequences. Essential
CC       component of a self-reinforcing loop coupling de novo DNA methylation
CC       to siRNA production. Required for intercellular but not intracellular
CC       RNA interference (RNAi) leading to systemic post-transcriptional gene
CC       silencing. Involved in the maintenance of post-transcriptional RNA
CC       silencing. {ECO:0000269|PubMed:19110459}.
CC   -!- SUBUNIT: Component of the RNA polymerase IV complex. Interacts with
CC       NRPD1. {ECO:0000269|PubMed:19110459, ECO:0000269|PubMed:21811420}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB03035.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AP001300; BAB03035.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002686; AEE76689.1; -; Genomic_DNA.
DR   EMBL; CP002686; ANM64801.1; -; Genomic_DNA.
DR   EMBL; AY085637; AAM62858.1; -; mRNA.
DR   RefSeq; NP_001326806.1; NM_001338603.1.
DR   RefSeq; NP_566719.1; NM_113190.3.
DR   AlphaFoldDB; Q8LE42; -.
DR   SMR; Q8LE42; -.
DR   BioGRID; 7194; 1.
DR   STRING; 3702.AT3G22900.1; -.
DR   PaxDb; Q8LE42; -.
DR   PRIDE; Q8LE42; -.
DR   ProteomicsDB; 250479; -.
DR   EnsemblPlants; AT3G22900.1; AT3G22900.1; AT3G22900.
DR   EnsemblPlants; AT3G22900.2; AT3G22900.2; AT3G22900.
DR   GeneID; 821862; -.
DR   Gramene; AT3G22900.1; AT3G22900.1; AT3G22900.
DR   Gramene; AT3G22900.2; AT3G22900.2; AT3G22900.
DR   KEGG; ath:AT3G22900; -.
DR   Araport; AT3G22900; -.
DR   TAIR; locus:2084573; AT3G22900.
DR   eggNOG; KOG3298; Eukaryota.
DR   HOGENOM; CLU_085878_3_0_1; -.
DR   InParanoid; Q8LE42; -.
DR   OMA; GDNPMFL; -.
DR   OrthoDB; 1140388at2759; -.
DR   PhylomeDB; Q8LE42; -.
DR   PRO; PR:Q8LE42; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q8LE42; baseline and differential.
DR   Genevisible; Q8LE42; AT.
DR   GO; GO:0000418; C:RNA polymerase IV complex; IDA:UniProtKB.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.30.1490.120; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR036898; RNA_pol_Rpb7-like_N_sf.
DR   InterPro; IPR045113; Rpb7-like.
DR   PANTHER; PTHR12709; PTHR12709; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF88798; SSF88798; 1.
PE   1: Evidence at protein level;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..174
FT                   /note="DNA-directed RNA polymerase IV subunit 7"
FT                   /id="PRO_0000423333"
SQ   SEQUENCE   174 AA;  19849 MW;  F9B1D02669771280 CRC64;
     MFIKVKLPWD VTIPAEDMDT GLMLQRAIVI RLLEAFSKEK ATKDLGYLIT PTILENIGEG
     KIKEQTGEIQ FPVVFNGICF KMFKGEIVHG VVHKVHKTGV FLKSGPYEII YLSHMKMPGY
     EFIPGENPFF MNQYMSRIQI GARVRFVVLD TEWREAEKDF MALASIDGDN LGPF
 
 
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