NRSN1_HUMAN
ID NRSN1_HUMAN Reviewed; 195 AA.
AC Q8IZ57; B2RAV4; Q8N8R6; Q96P21;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Neurensin-1;
DE AltName: Full=Neuro-p24;
DE AltName: Full=Vesicular membrane protein of 24 kDa;
DE Short=Vesicular membrane protein p24;
GN Name=NRSN1 {ECO:0000312|HGNC:HGNC:17881}; Synonyms=VMP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL14639.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain {ECO:0000269|PubMed:12463420};
RX PubMed=12463420; DOI=10.1023/a:1020402410522;
RA Cheng C., Xu J., Ye X., Dai J., Wu Q., Zeng L., Wang L., Zhao W., Ji C.,
RA Gu S., Xie Y., Mao Y.;
RT "Cloning, expression and characterization of a novel human VMP gene.";
RL Mol. Biol. Rep. 29:281-286(2002).
RN [2] {ECO:0000312|EMBL:BAC04748.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Teratocarcinoma {ECO:0000269|PubMed:14702039};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000312|EMBL:AAH23514.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAH23514.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play an important role in neural organelle transport, and
CC in transduction of nerve signals or in nerve growth. May play a role in
CC neurite extension. May play a role in memory consolidation (By
CC similarity). {ECO:0000250|UniProtKB:P97799,
CC ECO:0000269|PubMed:12463420}.
CC -!- INTERACTION:
CC Q8IZ57; Q969F0: FATE1; NbExp=3; IntAct=EBI-10264528, EBI-743099;
CC Q8IZ57; P12314: FCGR1A; NbExp=3; IntAct=EBI-10264528, EBI-2869867;
CC Q8IZ57; Q99795: GPA33; NbExp=3; IntAct=EBI-10264528, EBI-4289554;
CC Q8IZ57; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-10264528, EBI-10329546;
CC Q8IZ57; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-10264528, EBI-13044680;
CC Q8IZ57; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-10264528, EBI-17498703;
CC Q8IZ57; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-10264528, EBI-2821497;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cell projection, neuron projection
CC {ECO:0000250|UniProtKB:P97799}.
CC -!- TISSUE SPECIFICITY: Expressed in brain. Not detectable in other tissues
CC tested. {ECO:0000269|PubMed:12463420}.
CC -!- SIMILARITY: Belongs to the VMP family. {ECO:0000255}.
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DR EMBL; AF418980; AAL14639.1; -; mRNA.
DR EMBL; AK096290; BAC04748.1; -; mRNA.
DR EMBL; AK314373; BAG37001.1; -; mRNA.
DR EMBL; FO393410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55439.1; -; Genomic_DNA.
DR EMBL; BC023514; AAH23514.1; -; mRNA.
DR CCDS; CCDS4549.1; -.
DR RefSeq; NP_542454.3; NM_080723.4.
DR AlphaFoldDB; Q8IZ57; -.
DR BioGRID; 126698; 181.
DR IntAct; Q8IZ57; 7.
DR STRING; 9606.ENSP00000367739; -.
DR TCDB; 8.A.122.1.1; the vesicular membrane neurensin/tmem74 (neurensin/tmem74) family.
DR PhosphoSitePlus; Q8IZ57; -.
DR BioMuta; NRSN1; -.
DR DMDM; 74750784; -.
DR MassIVE; Q8IZ57; -.
DR PaxDb; Q8IZ57; -.
DR PeptideAtlas; Q8IZ57; -.
DR PRIDE; Q8IZ57; -.
DR ProteomicsDB; 71280; -.
DR Antibodypedia; 58910; 104 antibodies from 20 providers.
DR DNASU; 140767; -.
DR Ensembl; ENST00000378478.5; ENSP00000367739.2; ENSG00000152954.12.
DR Ensembl; ENST00000378491.9; ENSP00000367752.4; ENSG00000152954.12.
DR GeneID; 140767; -.
DR KEGG; hsa:140767; -.
DR MANE-Select; ENST00000378491.9; ENSP00000367752.4; NM_080723.5; NP_542454.3.
DR UCSC; uc010jpq.1; human.
DR CTD; 140767; -.
DR DisGeNET; 140767; -.
DR GeneCards; NRSN1; -.
DR HGNC; HGNC:17881; NRSN1.
DR HPA; ENSG00000152954; Group enriched (brain, choroid plexus).
DR MIM; 616630; gene.
DR neXtProt; NX_Q8IZ57; -.
DR OpenTargets; ENSG00000152954; -.
DR PharmGKB; PA38254; -.
DR VEuPathDB; HostDB:ENSG00000152954; -.
DR eggNOG; ENOG502QRNK; Eukaryota.
DR GeneTree; ENSGT00530000063877; -.
DR InParanoid; Q8IZ57; -.
DR OMA; TMAACLL; -.
DR OrthoDB; 1530336at2759; -.
DR PhylomeDB; Q8IZ57; -.
DR TreeFam; TF332090; -.
DR PathwayCommons; Q8IZ57; -.
DR SignaLink; Q8IZ57; -.
DR BioGRID-ORCS; 140767; 10 hits in 1065 CRISPR screens.
DR GeneWiki; NRSN1; -.
DR GenomeRNAi; 140767; -.
DR Pharos; Q8IZ57; Tbio.
DR PRO; PR:Q8IZ57; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8IZ57; protein.
DR Bgee; ENSG00000152954; Expressed in dorsolateral prefrontal cortex and 124 other tissues.
DR ExpressionAtlas; Q8IZ57; baseline and differential.
DR Genevisible; Q8IZ57; HS.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
DR GO; GO:0030133; C:transport vesicle; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR InterPro; IPR024883; Neurensin.
DR InterPro; IPR029698; Nrsn1.
DR PANTHER; PTHR14796; PTHR14796; 1.
DR PANTHER; PTHR14796:SF6; PTHR14796:SF6; 1.
PE 1: Evidence at protein level;
KW Cell projection; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..195
FT /note="Neurensin-1"
FT /id="PRO_0000270583"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 41
FT /note="I -> V (in dbSNP:rs17299946)"
FT /id="VAR_029816"
FT VARIANT 104
FT /note="H -> Y (in dbSNP:rs11544636)"
FT /id="VAR_053737"
FT CONFLICT 138
FT /note="V -> A (in Ref. 1; AAL14639)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="I -> T (in Ref. 2; BAC04748)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 195 AA; 21475 MW; BFADD774F04279D6 CRC64;
MSSCSNVCGS RQAQAAAEGG YQRYGVRSYL HQFYEDCTAS IWEYEDDFQI QRSPNRWSSV
FWKVGLISGT VFVILGLTVL AVGFLVPPKI EAFGEADFVV VDTHAVQFNS ALDMYKLAGA
VLFCIGGTSM AGCLLMSVFV KSYSKEEKFL QQKFKERIAD IKAHTQPVTK APGPGETKIP
VTLSRVQNVQ PLLAT
