NRSN1_MOUSE
ID NRSN1_MOUSE Reviewed; 196 AA.
AC P97799;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Neurensin-1;
DE AltName: Full=Neuro-p24;
DE AltName: Full=Vesicular membrane protein of 24 kDa;
DE Short=Vesicular membrane protein p24;
GN Name=Nrsn1 {ECO:0000312|MGI:MGI:894662};
GN Synonyms=Vmp {ECO:0000312|MGI:MGI:894662};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAA18947.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAA18947.1};
RC TISSUE=Brain {ECO:0000312|EMBL:BAA18947.1};
RX PubMed=9191101; DOI=10.1016/s0169-328x(97)00023-5;
RA Kadota Y., Niiya A., Masaki R., Yamamoto A., Araki M., Taketani S.;
RT "A newly identified membrane protein localized exclusively in intracellular
RT organelles of neurons.";
RL Brain Res. Mol. Brain Res. 46:265-273(1997).
RN [2] {ECO:0000312|EMBL:BAE23574.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE23574.1};
RC TISSUE=Hypothalamus {ECO:0000312|EMBL:BAE23574.1}, and
RC Thymus {ECO:0000312|EMBL:BAE32162.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000312|EMBL:AAH52019.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH52019.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAH52019.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=12445626; DOI=10.1016/s0168-0102(02)00156-6;
RA Araki M., Nagata K., Satoh Y., Kadota Y., Hisha H., Adachi Y., Taketani S.;
RT "Developmentally regulated expression of Neuro-p24 and its possible
RT function in neurite extension.";
RL Neurosci. Res. 44:379-389(2002).
RN [6] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=16527258; DOI=10.1016/j.brainres.2006.01.085;
RA Nakanishi K., Ida M., Suzuki H., Kitano C., Yamamoto A., Mori N., Araki M.,
RA Taketani S.;
RT "Molecular characterization of a transport vesicle protein Neurensin-2, a
RT homologue of Neurensin-1, expressed in neural cells.";
RL Brain Res. 1081:1-8(2006).
RN [7] {ECO:0000305}
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16696124; DOI=10.1016/j.brainres.2005.12.131;
RA Nagata K., Suzuki H., Niiya-Kato A., Kinoshita S., Taketani S., Araki M.;
RT "Neurensin-1 expression in the mouse retina during postnatal development
RT and in the cultured retinal neurons.";
RL Brain Res. 1081:65-71(2006).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [9]
RP FUNCTION, AND INDUCTION.
RX PubMed=26430118; DOI=10.1126/science.aac7368;
RA Cho J., Yu N.K., Choi J.H., Sim S.E., Kang S.J., Kwak C., Lee S.W.,
RA Kim J.I., Choi D.I., Kim V.N., Kaang B.K.;
RT "Multiple repressive mechanisms in the hippocampus during memory
RT formation.";
RL Science 350:82-87(2015).
CC -!- FUNCTION: May play an important role in neural organelle transport, and
CC in transduction of nerve signals or in nerve growth (PubMed:12445626,
CC PubMed:16527258, PubMed:16696124, PubMed:9191101). May play a role in
CC neurite extension (PubMed:26430118). {ECO:0000269|PubMed:12445626,
CC ECO:0000269|PubMed:16527258, ECO:0000269|PubMed:16696124,
CC ECO:0000269|PubMed:26430118, ECO:0000269|PubMed:9191101}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cell projection, neuron projection
CC {ECO:0000269|PubMed:16527258}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in brain. Also weakly
CC expressed in lung and spleen. In brain, expressed strongly in nerve
CC fibers of the cerebral cortex, anterior cerebral nuclei, hypothalamus,
CC amygdaloid complex, brain stem of the metaencephalon and medulla
CC oblongata, and moderately expressed in soma of neurons of the dentate
CC gyrus of the hippocampus and Purkinje cells of the cerebellum.
CC {ECO:0000269|PubMed:9191101}.
CC -!- DEVELOPMENTAL STAGE: Expression is developmentally regulated as axonal
CC fibers innervate, extend collateral fibers and finally attain a stable
CC state. First detected at postnatal day 6 in cell bodies and apical
CC dendrites of pyramidal neurons in the developing cerebral cortex, with
CC expression gradually increasing during postnatal development. In P1
CC retina, strongly expressed in the optic nerve fiber layer, and weakly
CC expressed in ganglion cells, presumptive amacrine and horizontal cells.
CC At P10, also strongly expressed in other parts of the retina such as
CC the ganglion cells, inner plexiform layer and horizontal cells.
CC Expression decreases as the retina develops further to maturity.
CC {ECO:0000269|PubMed:12445626, ECO:0000269|PubMed:16696124}.
CC -!- INDUCTION: By retinoic acid in neuroblastoma Neuro2a cells. Down-
CC regulated following fear conditioning (at protein level)
CC (PubMed:26430118). {ECO:0000269|PubMed:16527258,
CC ECO:0000269|PubMed:26430118, ECO:0000269|PubMed:9191101}.
CC -!- SIMILARITY: Belongs to the VMP family. {ECO:0000255}.
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DR EMBL; D83206; BAA18947.1; -; mRNA.
DR EMBL; AK138191; BAE23574.1; -; mRNA.
DR EMBL; AK153741; BAE32162.1; -; mRNA.
DR EMBL; AL589766; CAI24436.1; -; Genomic_DNA.
DR EMBL; BC052019; AAH52019.1; -; mRNA.
DR CCDS; CCDS26387.1; -.
DR RefSeq; NP_033539.1; NM_009513.2.
DR RefSeq; XP_011242608.1; XM_011244306.2.
DR RefSeq; XP_017170992.1; XM_017315503.1.
DR AlphaFoldDB; P97799; -.
DR CORUM; P97799; -.
DR STRING; 10090.ENSMUSP00000055048; -.
DR iPTMnet; P97799; -.
DR PhosphoSitePlus; P97799; -.
DR PaxDb; P97799; -.
DR PRIDE; P97799; -.
DR ProteomicsDB; 293973; -.
DR Antibodypedia; 58910; 104 antibodies from 20 providers.
DR Ensembl; ENSMUST00000057866; ENSMUSP00000055048; ENSMUSG00000048978.
DR Ensembl; ENSMUST00000167305; ENSMUSP00000128979; ENSMUSG00000048978.
DR GeneID; 22360; -.
DR KEGG; mmu:22360; -.
DR UCSC; uc007pwx.2; mouse.
DR CTD; 140767; -.
DR MGI; MGI:894662; Nrsn1.
DR VEuPathDB; HostDB:ENSMUSG00000048978; -.
DR eggNOG; ENOG502QRNK; Eukaryota.
DR GeneTree; ENSGT00530000063877; -.
DR HOGENOM; CLU_118170_1_0_1; -.
DR InParanoid; P97799; -.
DR OMA; TMAACLL; -.
DR OrthoDB; 1530336at2759; -.
DR PhylomeDB; P97799; -.
DR TreeFam; TF332090; -.
DR BioGRID-ORCS; 22360; 0 hits in 72 CRISPR screens.
DR PRO; PR:P97799; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; P97799; protein.
DR Bgee; ENSMUSG00000048978; Expressed in primary visual cortex and 131 other tissues.
DR Genevisible; P97799; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
DR GO; GO:0030426; C:growth cone; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IDA:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IDA:MGI.
DR GO; GO:0030133; C:transport vesicle; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEP:UniProtKB.
DR InterPro; IPR024883; Neurensin.
DR InterPro; IPR029698; Nrsn1.
DR PANTHER; PTHR14796; PTHR14796; 1.
DR PANTHER; PTHR14796:SF6; PTHR14796:SF6; 1.
PE 1: Evidence at protein level;
KW Cell projection; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..196
FT /note="Neurensin-1"
FT /id="PRO_0000270584"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 196 AA; 21595 MW; F866AB20ADB934BF CRC64;
MTSCSNTCGS RRAQADTEGG YQQRYGVRSY LHQFYEDCTA SIWEYEDDFQ IQRSPNRWSS
VFWKVGLISG TVFVILGLTV LAVGFLVPPK IEAFGEADFM VVDTHAVKYN GALDTCKLAG
AVLFCIGGTS MAGCLLMSVF AKSYSKEEKF LQQKFKERIA DIKAHTQPIT KAPGPGDTKI
PVTLSRVQNV QPLSAT
