NRSN2_HUMAN
ID NRSN2_HUMAN Reviewed; 204 AA.
AC Q9GZP1; A8K3B2; Q6FII5; Q9NUD3;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Neurensin-2;
GN Name=NRSN2; Synonyms=C20orf98;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in maintenance and/or transport of vesicles.
CC -!- INTERACTION:
CC Q9GZP1; O43765: SGTA; NbExp=3; IntAct=EBI-724857, EBI-347996;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the VMP family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AL136915; CAB66849.1; -; mRNA.
DR EMBL; AK026982; BAB15613.1; -; mRNA.
DR EMBL; AK290527; BAF83216.1; -; mRNA.
DR EMBL; CR533441; CAG38472.1; -; mRNA.
DR EMBL; AL034548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10680.1; -; Genomic_DNA.
DR EMBL; BC001963; AAH01963.1; -; mRNA.
DR CCDS; CCDS12996.1; -.
DR RefSeq; NP_001310608.1; NM_001323679.1.
DR RefSeq; NP_001310609.1; NM_001323680.1.
DR RefSeq; NP_001310610.1; NM_001323681.1.
DR RefSeq; NP_001310611.1; NM_001323682.1.
DR RefSeq; NP_001310612.1; NM_001323683.1.
DR RefSeq; NP_001310613.1; NM_001323684.1.
DR RefSeq; NP_001310614.1; NM_001323685.1.
DR RefSeq; NP_079234.1; NM_024958.2.
DR RefSeq; XP_006723693.1; XM_006723630.3.
DR RefSeq; XP_011527662.1; XM_011529360.1.
DR RefSeq; XP_011527664.1; XM_011529362.2.
DR RefSeq; XP_011527665.1; XM_011529363.2.
DR RefSeq; XP_016883562.1; XM_017028073.1.
DR RefSeq; XP_016883563.1; XM_017028074.1.
DR RefSeq; XP_016883564.1; XM_017028075.1.
DR AlphaFoldDB; Q9GZP1; -.
DR BioGRID; 123077; 15.
DR IntAct; Q9GZP1; 11.
DR STRING; 9606.ENSP00000371728; -.
DR TCDB; 8.A.122.1.2; the vesicular membrane neurensin/tmem74 (neurensin/tmem74) family.
DR iPTMnet; Q9GZP1; -.
DR PhosphoSitePlus; Q9GZP1; -.
DR SwissPalm; Q9GZP1; -.
DR BioMuta; NRSN2; -.
DR DMDM; 25008324; -.
DR MassIVE; Q9GZP1; -.
DR PaxDb; Q9GZP1; -.
DR PeptideAtlas; Q9GZP1; -.
DR PRIDE; Q9GZP1; -.
DR ProteomicsDB; 80104; -.
DR Antibodypedia; 3000; 182 antibodies from 27 providers.
DR DNASU; 80023; -.
DR Ensembl; ENST00000382285.7; ENSP00000371722.2; ENSG00000125841.13.
DR Ensembl; ENST00000382291.7; ENSP00000371728.3; ENSG00000125841.13.
DR Ensembl; ENST00000621012.1; ENSP00000482706.1; ENSG00000125841.13.
DR GeneID; 80023; -.
DR KEGG; hsa:80023; -.
DR MANE-Select; ENST00000382285.7; ENSP00000371722.2; NM_001323682.2; NP_001310611.1.
DR UCSC; uc002wdi.5; human.
DR CTD; 80023; -.
DR DisGeNET; 80023; -.
DR GeneCards; NRSN2; -.
DR HGNC; HGNC:16229; NRSN2.
DR HPA; ENSG00000125841; Tissue enhanced (brain).
DR MIM; 610666; gene.
DR neXtProt; NX_Q9GZP1; -.
DR OpenTargets; ENSG00000125841; -.
DR PharmGKB; PA25805; -.
DR VEuPathDB; HostDB:ENSG00000125841; -.
DR eggNOG; ENOG502S1MN; Eukaryota.
DR GeneTree; ENSGT00530000063877; -.
DR HOGENOM; CLU_118170_0_0_1; -.
DR InParanoid; Q9GZP1; -.
DR OMA; CWKITLS; -.
DR OrthoDB; 1530336at2759; -.
DR PhylomeDB; Q9GZP1; -.
DR TreeFam; TF332090; -.
DR PathwayCommons; Q9GZP1; -.
DR SignaLink; Q9GZP1; -.
DR BioGRID-ORCS; 80023; 9 hits in 1073 CRISPR screens.
DR ChiTaRS; NRSN2; human.
DR GeneWiki; NRSN2; -.
DR GenomeRNAi; 80023; -.
DR Pharos; Q9GZP1; Tbio.
DR PRO; PR:Q9GZP1; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9GZP1; protein.
DR Bgee; ENSG00000125841; Expressed in right frontal lobe and 118 other tissues.
DR ExpressionAtlas; Q9GZP1; baseline and differential.
DR Genevisible; Q9GZP1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:LIFEdb.
DR GO; GO:0030133; C:transport vesicle; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR InterPro; IPR024883; Neurensin.
DR InterPro; IPR029701; Nrsn2.
DR PANTHER; PTHR14796; PTHR14796; 1.
DR PANTHER; PTHR14796:SF5; PTHR14796:SF5; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..204
FT /note="Neurensin-2"
FT /id="PRO_0000221675"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 178..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 41
FT /note="L -> V (in dbSNP:rs11556643)"
FT /id="VAR_053738"
FT VARIANT 65
FT /note="S -> C (in dbSNP:rs17762763)"
FT /id="VAR_053739"
FT VARIANT 160
FT /note="E -> Q (in dbSNP:rs35731713)"
FT /id="VAR_062158"
SQ SEQUENCE 204 AA; 21983 MW; D20FAAE67C0FF16D CRC64;
MMPSCNRSCS CSRGPSVEDG KWYGVRSYLH LFYEDCAGTA LSDDPEGPPV LCPRRPWPSL
CWKISLSSGT LLLLLGVAAL TTGYAVPPKL EGIGEGEFLV LDQRAADYNQ ALGTCRLAGT
ALCVAAGVLL AICLFWAMIG WLSQDTKAEP LDPEADSHVE VFGDEPEQQL SPIFRNASGQ
SWFSPPASPF GQSSVQTIQP KRDS
