NRSN2_MOUSE
ID NRSN2_MOUSE Reviewed; 202 AA.
AC Q5HZK2; A2AS81; Q3USR0;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Neurensin-2;
GN Name=Nrsn2 {ECO:0000312|MGI:MGI:2684969};
GN Synonyms=Gm123 {ECO:0000312|MGI:MGI:2684969};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=16527258; DOI=10.1016/j.brainres.2006.01.085;
RA Nakanishi K., Ida M., Suzuki H., Kitano C., Yamamoto A., Mori N., Araki M.,
RA Taketani S.;
RT "Molecular characterization of a transport vesicle protein Neurensin-2, a
RT homologue of Neurensin-1, expressed in neural cells.";
RL Brain Res. 1081:1-8(2006).
RN [2] {ECO:0000312|EMBL:BAE24271.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE24271.1};
RC TISSUE=Corpora quadrigemina {ECO:0000312|EMBL:BAE24271.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000312|EMBL:AAH88982.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH88982.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAH88982.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in maintenance and/or transport of vesicles.
CC {ECO:0000269|PubMed:16527258}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in brain where it is widely
CC expressed, with highest levels of expression in thalamus and
CC hypothalamus. In brain, found in neural cell bodies and detected in
CC many regions of the limbic system, such as the septum nucleus,
CC horizontal and vertical limbs of the diagonal band, hippocampus,
CC amygdaloid nucleus, and habernula nucleus. Also localizes to small
CC vesicles found in the perinuclear region of Neuro2a and PC12 cells.
CC {ECO:0000269|PubMed:16527258}.
CC -!- DEVELOPMENTAL STAGE: In cerebral cortex first detected at 15.5 dpc with
CC increasing levels of expression observed during postnatal stages.
CC {ECO:0000269|PubMed:16527258}.
CC -!- SIMILARITY: Belongs to the VMP family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE24271.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK140190; BAE24271.1; ALT_FRAME; mRNA.
DR EMBL; AL928568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC088982; AAH88982.1; -; mRNA.
DR CCDS; CCDS16882.1; -.
DR RefSeq; NP_001009948.1; NM_001009948.1.
DR AlphaFoldDB; Q5HZK2; -.
DR STRING; 10090.ENSMUSP00000078260; -.
DR iPTMnet; Q5HZK2; -.
DR PhosphoSitePlus; Q5HZK2; -.
DR PaxDb; Q5HZK2; -.
DR PRIDE; Q5HZK2; -.
DR ProteomicsDB; 293749; -.
DR Antibodypedia; 3000; 182 antibodies from 27 providers.
DR DNASU; 228777; -.
DR Ensembl; ENSMUST00000079278; ENSMUSP00000078260; ENSMUSG00000059361.
DR GeneID; 228777; -.
DR KEGG; mmu:228777; -.
DR UCSC; uc008nfh.1; mouse.
DR CTD; 80023; -.
DR MGI; MGI:2684969; Nrsn2.
DR VEuPathDB; HostDB:ENSMUSG00000059361; -.
DR eggNOG; ENOG502S1MN; Eukaryota.
DR GeneTree; ENSGT00530000063877; -.
DR HOGENOM; CLU_118170_0_0_1; -.
DR InParanoid; Q5HZK2; -.
DR OMA; CWKITLS; -.
DR OrthoDB; 1530336at2759; -.
DR PhylomeDB; Q5HZK2; -.
DR TreeFam; TF332090; -.
DR BioGRID-ORCS; 228777; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q5HZK2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q5HZK2; protein.
DR Bgee; ENSMUSG00000059361; Expressed in superior frontal gyrus and 78 other tissues.
DR Genevisible; Q5HZK2; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0030133; C:transport vesicle; IDA:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR InterPro; IPR024883; Neurensin.
DR InterPro; IPR029701; Nrsn2.
DR PANTHER; PTHR14796; PTHR14796; 1.
DR PANTHER; PTHR14796:SF5; PTHR14796:SF5; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..202
FT /note="Neurensin-2"
FT /id="PRO_0000270585"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 162..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 202 AA; 22415 MW; 9C68F26BD372980C CRC64;
MSCSRPCVCS HGTSVEESTW YGFDFYPNLF YNDWLGTTTL PYNPERIPIR YINRPWPSLC
WKVTVAVASL FLLLGVAALT TGYAVPPKLE LVNESKFSSM EDPVADYNQA LMTCRVVGAT
LCGVAGIMLA VCLFLIASGW MFQDIKAEPL VTETDSPVEV FRDEPEKLSP AFHETSSQSP
FLTPPSPFGQ QSVQTSQPQR DL
