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NRT24_ARATH
ID   NRT24_ARATH             Reviewed;         527 AA.
AC   Q9FJH8;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=High affinity nitrate transporter 2.4;
DE            Short=AtNRT2:4;
GN   Name=NRT2.4; OrderedLocusNames=At5g60770; ORFNames=MAE1.2, MAE1.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA   Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT   features of the regions of 1,013,767 bp covered by sixteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:297-308(1998).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=11912225; DOI=10.1093/jexbot/53.370.825;
RA   Orsel M., Filleur S., Fraisier V., Daniel-Vedele F.;
RT   "Nitrate transport in plants: which gene and which control?";
RL   J. Exp. Bot. 53:825-833(2002).
RN   [5]
RP   TISSUE SPECIFICITY, INDUCTION BY NITRATE, AND GENE FAMILY.
RX   PubMed=12668777; DOI=10.1093/pcp/pcg036;
RA   Okamoto M., Vidmar J.J., Glass A.D.;
RT   "Regulation of NRT1 and NRT2 gene families of Arabidopsis thaliana:
RT   responses to nitrate provision.";
RL   Plant Cell Physiol. 44:304-317(2003).
RN   [6]
RP   FUNCTION, AND INDUCTION BY NITRATE.
RX   PubMed=15107992; DOI=10.1007/s00425-004-1266-x;
RA   Orsel M., Eulenburg K., Krapp A., Daniel-Vedele F.;
RT   "Disruption of the nitrate transporter genes AtNRT2.1 and AtNRT2.2
RT   restricts growth at low external nitrate concentration.";
RL   Planta 219:714-721(2004).
RN   [7]
RP   GENE FAMILY.
RX   PubMed=17481610; DOI=10.1016/j.febslet.2007.04.047;
RA   Tsay Y.F., Chiu C.C., Tsai C.B., Ho C.H., Hsu P.K.;
RT   "Nitrate transporters and peptide transporters.";
RL   FEBS Lett. 581:2290-2300(2007).
CC   -!- FUNCTION: Involved in high-affinity nitrate transport. Might be
CC       involved in the transfer of nitrate from stored pools to cytoplasm.
CC       {ECO:0000269|PubMed:15107992}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots and shoots.
CC       {ECO:0000269|PubMed:12668777}.
CC   -!- INDUCTION: Low transient up-regulation by nitrate both in shoots and
CC       roots. Very low induction by growth on low nitrate concentration, but
CC       strong induction in mutant with disruption in both NRT21. and NRT2.2.
CC       However, this overexpression could not restore the nitrate influx.
CC       {ECO:0000269|PubMed:12668777, ECO:0000269|PubMed:15107992}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Nitrate/nitrite porter (TC 2.A.1.8) family. {ECO:0000305}.
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DR   EMBL; DQ056732; AAY78876.1; -; mRNA.
DR   EMBL; AB015472; BAB10098.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97375.1; -; Genomic_DNA.
DR   RefSeq; NP_200885.1; NM_125470.2.
DR   AlphaFoldDB; Q9FJH8; -.
DR   SMR; Q9FJH8; -.
DR   BioGRID; 21442; 1.
DR   STRING; 3702.AT5G60770.1; -.
DR   PaxDb; Q9FJH8; -.
DR   PRIDE; Q9FJH8; -.
DR   EnsemblPlants; AT5G60770.1; AT5G60770.1; AT5G60770.
DR   GeneID; 836198; -.
DR   Gramene; AT5G60770.1; AT5G60770.1; AT5G60770.
DR   KEGG; ath:AT5G60770; -.
DR   Araport; AT5G60770; -.
DR   TAIR; locus:2159280; AT5G60770.
DR   eggNOG; ENOG502QPIC; Eukaryota.
DR   HOGENOM; CLU_024204_0_0_1; -.
DR   OMA; MADGFGE; -.
DR   OrthoDB; 542533at2759; -.
DR   PhylomeDB; Q9FJH8; -.
DR   PRO; PR:Q9FJH8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FJH8; baseline and differential.
DR   Genevisible; Q9FJH8; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0015112; F:nitrate transmembrane transporter activity; IGI:TAIR.
DR   GO; GO:0071249; P:cellular response to nitrate; IGI:TAIR.
DR   GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR   GO; GO:0015706; P:nitrate transmembrane transport; IMP:CACAO.
DR   CDD; cd17341; MFS_NRT2_like; 1.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR044772; NO3_transporter.
DR   PANTHER; PTHR23515; PTHR23515; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Nitrate assimilation; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..527
FT                   /note="High affinity nitrate transporter 2.4"
FT                   /id="PRO_0000400101"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        441..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          497..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   527 AA;  57768 MW;  9F9BA621E8606AC4 CRC64;
     MADGFGEPGS SMHGVTGREQ SYAFSVESPA VPSDSSAKFS LPVDTEHKAK VFKLLSFEAP
     HMRTFHLAWI SFFTCFISTF AAAPLVPIIR DNLNLTRQDV GNAGVASVSG SIFSRLVMGA
     VCDLLGPRYG CAFLVMLSAP TVFSMSFVGG AGGYITVRFM IGFCLATFVS CQYWMSTMFN
     GQIIGLVNGT AAGWGNMGGG VTQLLMPMVY EIIRRLGSTS FTAWRMAFFV PGWMHIIMGI
     LVLTLGQDLP DGNRSTLEKK GAVTKDKFSK VLWYAITNYR TWVFVLLYGY SMGVELTTDN
     VIAEYFFDRF HLKLHTAGII AASFGMANFF ARPIGGWASD IAARRFGMRG RLWTLWIIQT
     LGGFFCLWLG RATTLPTAVV FMILFSLGAQ AACGATFAII PFISRRSLGI ISGLTGAGGN
     FGSGLTQLVF FSTSTFSTEQ GLTWMGVMIM ACTLPVTLVH FPQWGSMFLP STEDEVKSTE
     EYYYMKEWTE TEKRKGMHEG SLKFAVNSRS ERGRRVASAP SPPPEHV
 
 
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