ID   NRTN_MOUSE              Reviewed;         195 AA.
AC   P97463;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Neurturin;
DE   Flags: Precursor;
GN   Name=Nrtn;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 96-110; 127-135;
RP   155-177 AND 181-190.
RX   PubMed=8945474; DOI=10.1038/384467a0;
RA   Kotzbauer P.T., Lampe P.A., Heuckeroth R.O., Golden J.P., Creedon D.J.,
RA   Johnson E.M. Jr., Milbrandt J.;
RT   "Neurturin, a relative of glial-cell-line-derived neurotrophic factor.";
RL   Nature 384:467-470(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Supports the survival of sympathetic neurons in culture. May
CC       regulate the development and maintenance of the CNS. Might control the
CC       size of non-neuronal cell population such as haemopoietic cells.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Widespread distribution.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U78109; AAC52954.1; -; mRNA.
DR   EMBL; BC057993; AAH57993.1; -; mRNA.
DR   CCDS; CCDS28913.1; -.
DR   RefSeq; NP_032764.1; NM_008738.3.
DR   RefSeq; XP_006523864.1; XM_006523801.2.
DR   AlphaFoldDB; P97463; -.
DR   SMR; P97463; -.
DR   BioGRID; 201850; 1.
DR   STRING; 10090.ENSMUSP00000046512; -.
DR   iPTMnet; P97463; -.
DR   PhosphoSitePlus; P97463; -.
DR   PaxDb; P97463; -.
DR   PRIDE; P97463; -.
DR   ProteomicsDB; 293897; -.
DR   Antibodypedia; 11762; 471 antibodies from 41 providers.
DR   DNASU; 18188; -.
DR   Ensembl; ENSMUST00000044752; ENSMUSP00000046512; ENSMUSG00000039481.
DR   GeneID; 18188; -.
DR   KEGG; mmu:18188; -.
DR   UCSC; uc008ddc.1; mouse.
DR   CTD; 4902; -.
DR   MGI; MGI:108417; Nrtn.
DR   VEuPathDB; HostDB:ENSMUSG00000039481; -.
DR   eggNOG; ENOG502QWH4; Eukaryota.
DR   GeneTree; ENSGT00950000182993; -.
DR   HOGENOM; CLU_102221_1_1_1; -.
DR   InParanoid; P97463; -.
DR   OMA; TFAFMLC; -.
DR   OrthoDB; 1373819at2759; -.
DR   PhylomeDB; P97463; -.
DR   TreeFam; TF332366; -.
DR   Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-MMU-8853659; RET signaling.
DR   BioGRID-ORCS; 18188; 2 hits in 71 CRISPR screens.
DR   PRO; PR:P97463; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; P97463; protein.
DR   Bgee; ENSMUSG00000039481; Expressed in vestibular membrane of cochlear duct and 120 other tissues.
DR   Genevisible; P97463; MM.
DR   GO; GO:0030424; C:axon; ISO:MGI.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IDA:MGI.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR   GO; GO:0021675; P:nerve development; IMP:MGI.
DR   GO; GO:0001755; P:neural crest cell migration; ISO:MGI.
DR   GO; GO:0031175; P:neuron projection development; ISO:MGI.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IGI:MGI.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR043401; GDNF_fam.
DR   InterPro; IPR001839; TGF-b_C.
DR   PANTHER; PTHR12173; PTHR12173; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Growth factor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..95
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000034012"
FT   CHAIN           96..195
FT                   /note="Neurturin"
FT                   /id="PRO_0000034013"
FT   DISULFID        101..163
FT                   /evidence="ECO:0000250"
FT   DISULFID        128..192
FT                   /evidence="ECO:0000250"
FT   DISULFID        132..194
FT                   /evidence="ECO:0000250"
FT   DISULFID        162
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   195 AA;  22219 MW;  ABE21BB35D417448 CRC64;
     MRRWKAAALV SLICSSLLSV WMCQEGLLLG HRLGPALAPL RRPPRTLDAR IARLAQYRAL
     LQGAPDAVEL RELSPWAARI PGPRRRAGPR RRRARPGARP CGLRELEVRV SELGLGYTSD
     ETVLFRYCAG ACEAAIRIYD LGLRRLRQRR RVRRERARAH PCCRPTAYED EVSFLDVHSR
     YHTLQELSAR ECACV