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NRX2A_RAT
ID   NRX2A_RAT               Reviewed;        1715 AA.
AC   Q63374; Q63375;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=Neurexin-2;
DE   AltName: Full=Neurexin II-alpha;
DE   AltName: Full=Neurexin-2-alpha;
DE   Flags: Precursor;
GN   Name=Nrxn2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 10A), VARIANT LEU-434, AND
RP   ALTERNATIVE SPLICING.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=1621094; DOI=10.1126/science.1621094;
RA   Ushkaryov Y.A., Petrenko A.G., Geppert M., Suedhof T.C.;
RT   "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin
RT   receptor and laminin.";
RL   Science 257:50-56(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [3]
RP   ALTERNATIVE SPLICING.
RX   PubMed=7695896; DOI=10.1016/0896-6273(95)90306-2;
RA   Ullrich B., Ushkaryov Y.A., Suedhof T.C.;
RT   "Cartography of neurexins: more than 1000 isoforms generated by alternative
RT   splicing and expressed in distinct subsets of neurons.";
RL   Neuron 14:497-507(1995).
RN   [4]
RP   INTERACTION WITH NXPH1.
RX   PubMed=9856994; DOI=10.1074/jbc.273.52.34716;
RA   Missler M., Hammer R.E., Suedhof T.C.;
RT   "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as
RT   an independently folding ligand-binding unit.";
RL   J. Biol. Chem. 273:34716-34723(1998).
RN   [5]
RP   INTERACTION WITH PATJ.
RX   PubMed=9647694; DOI=10.1006/mcne.1998.0679;
RA   Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.;
RT   "CIPP, a novel multivalent PDZ domain protein, selectively interacts with
RT   Kir4.0 family members, NMDA receptor subunits, neurexins, and
RT   neuroligins.";
RL   Mol. Cell. Neurosci. 11:161-172(1998).
RN   [6]
RP   INTERACTION WITH ALPHA-DYSTROGLYCAN.
RX   PubMed=11470830; DOI=10.1083/jcb.200105003;
RA   Sugita S., Saito F., Tang J., Satz J., Campbell K., Suedhof T.C.;
RT   "A stoichiometric complex of neurexins and dystroglycan in brain.";
RL   J. Cell Biol. 154:435-445(2001).
CC   -!- FUNCTION: Neuronal cell surface protein that may be involved in cell
CC       recognition and cell adhesion. May mediate intracellular signaling.
CC   -!- SUBUNIT: The laminin G-like domain 1 binds to NXPH1 (PubMed:9856994).
CC       Interacts with PATJ (PubMed:9647694). Interacts with CBLN1, CBLN2 and,
CC       less avidly, with CBLN4 (By similarity). Isoforms alpha 2C bind to
CC       alpha-dystroglycan (PubMed:11470830). Interacts (via Laminin G-like 1
CC       domain) with IGSF21 (Ig-like 1 domain) in a trans-interaction manner
CC       (By similarity). {ECO:0000250|UniProtKB:E9Q7X7,
CC       ECO:0000269|PubMed:11470830, ECO:0000269|PubMed:9647694,
CC       ECO:0000269|PubMed:9856994}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage, Alternative splicing; Named isoforms=18;
CC         Comment=Two isoform types, alpha-type and beta-type are produced by
CC         alternative promoter usage. In addition there are at least five major
CC         alternatively spliced sites, each of which may be spliced in up to
CC         three different ways. Additional isoforms may derive from a minor
CC         cytoplasmic splice site 6. Combinatorial splicing at each of these
CC         six sites may lead to the generation of at least 216 isoforms but for
CC         simplicity only individual splice events are explicitly described
CC         below. Beta-type isoforms share the possibility of alternative
CC         splicing at sites 4, 5 and 6. Experimental confirmation may be
CC         lacking for some isoforms. {ECO:0000269|PubMed:1621094,
CC         ECO:0000269|PubMed:7695896};
CC       Name=1a; Synonyms=Alpha-1A2A3A4A5A;
CC         IsoId=Q63374-1; Sequence=Displayed;
CC       Name=2a; Synonyms=Alpha-1B;
CC         IsoId=Q63374-2; Sequence=VSP_003509;
CC       Name=3a; Synonyms=Alpha-1C;
CC         IsoId=Q63374-3; Sequence=VSP_003510;
CC       Name=4a; Synonyms=Alpha-2B;
CC         IsoId=Q63374-4; Sequence=VSP_003512;
CC       Name=5a; Synonyms=Alpha-2C;
CC         IsoId=Q63374-5; Sequence=VSP_003511;
CC       Name=6a; Synonyms=Alpha-3B;
CC         IsoId=Q63374-6; Sequence=VSP_003514;
CC       Name=7a; Synonyms=Alpha-3C;
CC         IsoId=Q63374-7; Sequence=VSP_003513;
CC       Name=8a; Synonyms=Alpha-4B;
CC         IsoId=Q63374-8; Sequence=VSP_003515;
CC       Name=9a; Synonyms=Alpha-5B;
CC         IsoId=Q63374-9; Sequence=VSP_003516;
CC       Name=10a; Synonyms=Alpha-6;
CC         IsoId=Q63374-10; Sequence=VSP_003517;
CC       Name=1b; Synonyms=Beta-4A5A;
CC         IsoId=Q63376-1; Sequence=External;
CC       Name=2b; Synonyms=Beta-4A5B;
CC         IsoId=Q63376-2; Sequence=External;
CC       Name=3b; Synonyms=Beta-4B5A;
CC         IsoId=Q63376-3; Sequence=External;
CC       Name=4b; Synonyms=Beta-4B5B;
CC         IsoId=Q63376-4; Sequence=External;
CC       Name=5b; Synonyms=Beta-4A5A6;
CC         IsoId=Q63376-5; Sequence=External;
CC       Name=6b; Synonyms=Beta-4A5B6;
CC         IsoId=Q63376-6; Sequence=External;
CC       Name=7b; Synonyms=Beta-4B5A6;
CC         IsoId=Q63376-7; Sequence=External;
CC       Name=8b; Synonyms=Beta-4B5B6;
CC         IsoId=Q63376-8; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Brain (neuronal synapse).
CC   -!- SIMILARITY: Belongs to the neurexin family. {ECO:0000305}.
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DR   EMBL; M96376; AAA41706.1; -; mRNA.
DR   EMBL; M96376; AAA41707.1; -; mRNA.
DR   EMBL; AABR03000676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03002856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03004066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03004601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03004809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03005995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03006603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03006786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03008290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03009435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; C40228; C40228.
DR   RefSeq; NP_446298.1; NM_053846.1.
DR   AlphaFoldDB; Q63374; -.
DR   SMR; Q63374; -.
DR   BioGRID; 250509; 4.
DR   IntAct; Q63374; 6.
DR   MINT; Q63374; -.
DR   STRING; 10116.ENSRNOP00000063600; -.
DR   GlyGen; Q63374; 4 sites.
DR   iPTMnet; Q63374; -.
DR   PhosphoSitePlus; Q63374; -.
DR   PaxDb; Q63374; -.
DR   PRIDE; Q63374; -.
DR   GeneID; 116595; -.
DR   KEGG; rno:116595; -.
DR   CTD; 9379; -.
DR   RGD; 620211; Nrxn2.
DR   eggNOG; KOG3514; Eukaryota.
DR   InParanoid; Q63374; -.
DR   Reactome; R-RNO-6794361; Neurexins and neuroligins.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:GOC.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0005246; F:calcium channel regulator activity; ISS:BHF-UCL.
DR   GO; GO:0050839; F:cell adhesion molecule binding; ISS:BHF-UCL.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0097109; F:neuroligin family protein binding; ISS:BHF-UCL.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; ISS:BHF-UCL.
DR   GO; GO:0030534; P:adult behavior; ISO:RGD.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; ISS:BHF-UCL.
DR   GO; GO:0097116; P:gephyrin clustering involved in postsynaptic density assembly; ISS:BHF-UCL.
DR   GO; GO:0097118; P:neuroligin clustering involved in postsynaptic membrane assembly; ISS:BHF-UCL.
DR   GO; GO:0007269; P:neurotransmitter secretion; ISS:BHF-UCL.
DR   GO; GO:0097119; P:postsynaptic density protein 95 clustering; ISS:BHF-UCL.
DR   GO; GO:0097104; P:postsynaptic membrane assembly; ISS:BHF-UCL.
DR   GO; GO:0007165; P:signal transduction; ISS:BHF-UCL.
DR   GO; GO:0035176; P:social behavior; ISO:RGD.
DR   GO; GO:0007416; P:synapse assembly; ISS:BHF-UCL.
DR   GO; GO:0042297; P:vocal learning; ISO:RGD.
DR   GO; GO:0071625; P:vocalization behavior; ISO:RGD.
DR   CDD; cd00110; LamG; 6.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR003585; Neurexin-like.
DR   Pfam; PF02210; Laminin_G_2; 6.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00282; LamG; 6.
DR   SUPFAM; SSF49899; SSF49899; 6.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE   1: Evidence at protein level;
KW   Alternative promoter usage; Alternative splicing; Calcium; Cell adhesion;
KW   Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Metal-binding;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000250"
FT   CHAIN           30..1715
FT                   /note="Neurexin-2"
FT                   /id="PRO_0000019496"
FT   TOPO_DOM        30..1639
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1640..1660
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1661..1715
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..206
FT                   /note="Laminin G-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          202..242
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          289..486
FT                   /note="Laminin G-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          493..686
FT                   /note="Laminin G-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          690..727
FT                   /note="EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          732..907
FT                   /note="Laminin G-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          921..1096
FT                   /note="Laminin G-like 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          1099..1136
FT                   /note="EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          1140..1348
FT                   /note="Laminin G-like 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   REGION          1461..1511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1529..1549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1583..1626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1682..1715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1583..1604
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1699..1715
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         335
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         352
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         420
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        338
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        844
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1239
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        206..219
FT                   /evidence="ECO:0000250"
FT   DISULFID        213..229
FT                   /evidence="ECO:0000250"
FT   DISULFID        231..241
FT                   /evidence="ECO:0000250"
FT   DISULFID        450..486
FT                   /evidence="ECO:0000250"
FT   DISULFID        657..686
FT                   /evidence="ECO:0000250"
FT   DISULFID        694..705
FT                   /evidence="ECO:0000250"
FT   DISULFID        699..714
FT                   /evidence="ECO:0000250"
FT   DISULFID        716..726
FT                   /evidence="ECO:0000250"
FT   DISULFID        1068..1096
FT                   /evidence="ECO:0000250"
FT   DISULFID        1103..1114
FT                   /evidence="ECO:0000250"
FT   DISULFID        1108..1123
FT                   /evidence="ECO:0000250"
FT   DISULFID        1125..1135
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         250..283
FT                   /note="Missing (in isoform 3a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003510"
FT   VAR_SEQ         250..259
FT                   /note="Missing (in isoform 2a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003509"
FT   VAR_SEQ         385..399
FT                   /note="Missing (in isoform 5a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003511"
FT   VAR_SEQ         393..399
FT                   /note="Missing (in isoform 4a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003512"
FT   VAR_SEQ         797..806
FT                   /note="DCLRVGCAPS -> G (in isoform 7a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003513"
FT   VAR_SEQ         807..809
FT                   /note="Missing (in isoform 6a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003514"
FT   VAR_SEQ         1256..1285
FT                   /note="Missing (in isoform 8a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003515"
FT   VAR_SEQ         1421..1614
FT                   /note="Missing (in isoform 9a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003516"
FT   VAR_SEQ         1667..1715
FT                   /note="DEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV ->
FT                   CRKSPREEKLLPGSAQGLGLDLAKACCVCRCRATCIAGKPLEERGGGRGEGERQMQIYI
FT                   KNK (in isoform 10a)"
FT                   /evidence="ECO:0000303|PubMed:1621094"
FT                   /id="VSP_003517"
FT   VARIANT         434
FT                   /note="N -> L"
FT                   /evidence="ECO:0000269|PubMed:1621094"
FT   CONFLICT        244
FT                   /note="G -> E (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        259
FT                   /note="P -> E (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        277
FT                   /note="D -> N (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        297
FT                   /note="F -> S (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        335
FT                   /note="D -> N (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        349
FT                   /note="V -> I (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        809
FT                   /note="G -> A (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        829
FT                   /note="V -> L (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        987
FT                   /note="G -> S (in Ref. 1; AAA41706/AAA41707)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1715 AA;  185169 MW;  C4A7A4129F25736C CRC64;
     MALGSRWRPP PQLPPLLLLL ALVAGVRGLE FGGGPGQWAR YARWAGAAST GELSFSLRTN
     ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT LQLDTPVADD RWHMVLLTRD
     ARRTALAVDG EARAAEVRSK RREMQVASDL FVGGIPPDVR LSALTLSTVK YEPPFRGLLA
     NLKLGERPPA LLGSQGLRGA AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF
     CSEGEHPMEG PAHLTLNSPV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
     DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI NLGSGAFEAL
     VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV TISVDGILTT TGYTQEDYTM
     LGSDDFFYIG GSPNTADLPG SPVSNNFMGC LKDVVYKNND FKLELSRLAK EGDPKMKLQG
     DLSFRCEDVA ALDPVTFESP EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGA
     GVGSHSSSQR ADYFAMELLD GYLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG
     SISVNSRSTP FLATGESEVL DLESELYLGG LPEGGRVDLP LPPEVWTAAL RAGYVGCVRD
     LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR NGGICREGWN RFVCDCIGTG
     FLGRVCEREA TVLSYDGSMY MKIMLPNAMH TEAEDVSLRF MSQRAYGLMM ATTSRESADT
     LRLELDGGQM KLTVNLDCLR VGCAPSAAGK GPETLFAGHK LNDNEWHTVR VVRRGKSLQL
     SVDNVTVEGQ MAGAHTRLEF HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK
     DGDITYCELN ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK TTAPDGLLLF
     NSGNGNDFIV IELVKGYIHY VFDLGNGPSL MKGNSDKPVN DNQWHNVVVS RDPGNVHTLK
     IDSRTVTQHS NGARNLDLKG ELYIGGLSKN MFSNLPKLVA SRDGFQGCLA SVDLNGRLPD
     LIADALHRIG QVERGCDGPS TTCTEESCAN QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT
     TYIFGKGGAL ITYTWPPNDR PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ
     GTVGVIFNVG TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN ERYPAGNFDN
     ERLAIARQRI PYRLGRVVDE WLLDKGRQLT IFNSQAAIKI GGRDQGRPFQ GQVSGLYYNG
     LKVLALAAES DPNVRTEGHL RLVGEGPSVL LSAETTATTL LADMATTIME TTTTMATTTT
     RRGRSPTMRD STTQNTDDLL VASAECPSDD EDLEECEPST GGELILPIIT EDSLDPPPVA
     TRSPFVPPPP TFYPFLTGVG ATQDTLPPPA ARRPSSGGPC QAERDDSDCE EPVEASGFAS
     GEVFDSSLPP TDDEDFYTTF PLVTDRTTLL SPRKPAPRPN LRTDGATGAP GVLLAPSAPA
     PNLPAGKMNH RDPLQPLLEN PPLGPGVPTA FEPRRPPPLR PGVTSVPGFP RLPTANPTGP
     GERGPPGAVE VIRESSSTTG MVVGIVAAAA LCILILLYAM YKYRNRDEGS YQVDQSRNYI
     SNSAQSNGAV VKEKAPAAPK TPSKAKKNKD KEYYV
 
 
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