ID   NS12_CVHOC              Reviewed;         109 AA.
AC   Q04853; Q696P7;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Non-structural protein of 12.9 kDa;
DE            Short=ns12.9;
DE   AltName: Full=12.9 kDa accessory protein;
DE   AltName: Full=NS2;
GN   ORFNames=5a;
OS   Human coronavirus OC43 (HCoV-OC43).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Embecovirus.
OX   NCBI_TaxID=31631;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8517026; DOI=10.1006/viro.1993.1043;
RA   Mounir S., Talbot P.J.;
RT   "Human coronavirus OC43 RNA 4 lacks two open reading frames located
RT   downstream of the S gene of bovine coronavirus.";
RL   Virology 192:355-360(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate ATCC VR-759, and Isolate clinical OC43-Paris;
RX   PubMed=15280490; DOI=10.1128/jvi.78.16.8824-8834.2004;
RA   St Jean J.R., Jacomy H., Desforges M., Vabret A., Freymuth F., Talbot P.J.;
RT   "Human respiratory coronavirus OC43: genetic stability and neuroinvasion.";
RL   J. Virol. 78:8824-8834(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate ATCC VR-759;
RX   PubMed=15650185; DOI=10.1128/jvi.79.3.1595-1604.2005;
RA   Vijgen L., Keyaerts E., Moes E., Thoelen I., Wollants E., Lemey P.,
RA   Vandamme A.M., Van Ranst M.;
RT   "Complete genomic sequence of human coronavirus OC43: molecular clock
RT   analysis suggests a relatively recent zoonotic coronavirus transmission
RT   event.";
RL   J. Virol. 79:1595-1604(2005).
CC   -!- FUNCTION: May act as membrane-anchoring region for structural proteins
CC       during virus assembly, or play a role in membrane association of the
CC       viral polymerase during replication.
CC   -!- SIMILARITY: Belongs to the coronaviruses ns12.7 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M99576; AAA02569.1; -; Genomic_RNA.
DR   EMBL; AY585228; AAT84355.1; -; Genomic_RNA.
DR   EMBL; AY585229; AAT84363.1; -; Genomic_RNA.
DR   EMBL; AY391777; AAR01016.1; -; Genomic_RNA.
DR   PIR; A44275; A44275.
DR   TCDB; 1.A.49.1.1; the human coronavirus ns12,9 viroporin (ns12,9) family.
DR   Proteomes; UP000007552; Genome.
DR   Proteomes; UP000100580; Genome.
DR   Proteomes; UP000180344; Genome.
DR   InterPro; IPR006841; Corona_NS2.
DR   Pfam; PF04753; Corona_NS12-7; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..109
FT                   /note="Non-structural protein of 12.9 kDa"
FT                   /id="PRO_0000106065"
SQ   SEQUENCE   109 AA;  12935 MW;  8F06A6E9E30B1667 CRC64;
     MDIWRPEKKY LRYINGFNVS ELEDACFKFN YQFPKVGYCR VPSHAWCRNQ GRFCATFTLY
     GKSKHYDKYF GVINGFTAFA NTVEDAVNKL VFLAVDFITW RRQELNVYG