NS1BA_DANRE
ID NS1BA_DANRE Reviewed; 643 AA.
AC Q5RG82; Q6NYP3; Q7ZUZ3;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Influenza virus NS1A-binding protein homolog A;
DE Short=NS1-BP homolog A;
DE Short=NS1-binding protein homolog A;
GN Name=ivns1abpa; ORFNames=si:dkeyp-11g8.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in cell division and in the dynamic organization
CC of the actin skeleton as a stabilizer of actin filaments by association
CC with F-actin through Kelch repeats. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
CC Note=Associated with actin filaments. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5RG82-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5RG82-2; Sequence=VSP_024814, VSP_024815;
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DR EMBL; BX957305; CAI21326.1; -; Genomic_DNA.
DR EMBL; BX957305; CAI21327.1; -; Genomic_DNA.
DR EMBL; BC046068; AAH46068.1; -; mRNA.
DR EMBL; BC066513; AAH66513.1; -; mRNA.
DR RefSeq; NP_954973.2; NM_199279.2. [Q5RG82-1]
DR AlphaFoldDB; Q5RG82; -.
DR SMR; Q5RG82; -.
DR STRING; 7955.ENSDARP00000061658; -.
DR PaxDb; Q5RG82; -.
DR PRIDE; Q5RG82; -.
DR Ensembl; ENSDART00000061659; ENSDARP00000061658; ENSDARG00000031100. [Q5RG82-1]
DR GeneID; 387591; -.
DR KEGG; dre:387591; -.
DR CTD; 387591; -.
DR ZFIN; ZDB-GENE-031222-2; ivns1abpa.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000155635; -.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; Q5RG82; -.
DR OMA; TWTFIAP; -.
DR OrthoDB; 251780at2759; -.
DR PhylomeDB; Q5RG82; -.
DR TreeFam; TF329218; -.
DR PRO; PR:Q5RG82; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000031100; Expressed in pharyngeal gill and 42 other tissues.
DR ExpressionAtlas; Q5RG82; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Kelch repeat; Nucleus;
KW Reference proteome; Repeat.
FT CHAIN 1..643
FT /note="Influenza virus NS1A-binding protein homolog A"
FT /id="PRO_0000285079"
FT DOMAIN 32..99
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 134..185
FT /note="BACK"
FT REPEAT 369..415
FT /note="Kelch 1"
FT REPEAT 416..463
FT /note="Kelch 2"
FT REPEAT 465..512
FT /note="Kelch 3"
FT REPEAT 513..559
FT /note="Kelch 4"
FT REPEAT 560..606
FT /note="Kelch 5"
FT REPEAT 608..643
FT /note="Kelch 6"
FT REGION 257..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 360..380
FT /note="GLGIASLNDQLIAAGGYNREE -> VSSQYLLFLIFPVLAFGVFSQ (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_024814"
FT VAR_SEQ 381..643
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_024815"
FT CONFLICT 582
FT /note="V -> A (in Ref. 2; AAH66513)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 643 AA; 71687 MW; 74AFCF4B55BACEFF CRC64;
MIPNGYLIFE DESFLDSTVA KMNALRKNGQ FCDVRLQVCG HELMAHRAVL ACCSPYLFEI
FNSDLEPHGI SHVKFEDLDP EAVEILLNYA YTAQLKADKE LVKEVYSAAK RLKMDRVKQI
CGDYLLSKMD SQSAISYRNF ASCMGDGRLL GKIDSYIQEH LLEVSEQEDF LKLPRLKLEV
MLEDNLTLPS NGKLYSKVIG WVQRSLWENG EPLERLMEEV QTLYYSADHK LLDGSLLDGQ
AEVFGTEDDH IQFVQKKPPR ENVHRQLSTS SSGSLSPGST KHPCKQEWKY IASEKTTNNT
YLCLAVLNGM LCVIFLHGRS SPQASPSATP CLTKSLSFEG QPLEEEPDKL LSPMHYARSG
LGIASLNDQL IAAGGYNREE CLRTVECYNI KTNSWTFIAP MRTPRARFQM AVLMGQLYVM
GGSNGHSDEL SCGETYNPNA DEWTQVPELR TNRCNAGVCS LNNKLYVVGG SDPCGQKGLK
NCDVFDPISK AWTNCAPLNI RRHQAAVCEL DGFMYVIGGA ESWNCLNSVE RYNPENNTWT
LIASMNIARR GAGVAVYEGK LFVVGGFDGS HALRCVEMYD PVRNEWRMLG SMNSPRSNAG
AAVLNDVIYA IGGFDGNDFL NSVEAYNPKT EEWSTCADAF TDS
